Regeneron · 12 hours ago
Senior Scientist (Oligonucleotide Therapeutics)
Tarrytown, NY
Full-time
Onsite
Mid, Senior Level
$108K/yr - $177K/yr
3+ years expRegeneron is seeking a curious and motivated Senior Scientist to join their Genetic Medicines group, focusing on oligonucleotide-based therapeutics. The role involves leading assay development, candidate screening, and optimization efforts to support therapeutic development.
BiopharmaBiotechnologyPharmaceutical
Responsibilities
Design and optimize siRNAs for target specificity and efficacy
Lead high-throughput screening (HTS) and secondary screening, including dose-response studies to determine IC50
Develop and validate screening assays (e.g., bDNA, RT-qPCR)
Implement automation for HTS and optimize screening systems (e.g., primary cells, reporter systems)
Establish off-target screening approaches
Use off-target data to guide SAR optimization and improve molecular design
Lead a multidisciplinary team, ensuring alignment with project goals
Collaborate with bioinformatics, automation, and chemistry teams
Qualification
Required
Ph.D. in Molecular Biology, Biochemistry, or related field
3+ years of experience in RNAi research, high throughput screening, and/or SAR optimization
Expertise in siRNA design, assay development, and off-target analysis
Proficiency in RT-qPCR, including probe designs and multiplex assay development
Experience with primary cells and reporter systems
Experience with automation systems and bDNA assays to support HTS
Knowledge of computational tools for transcriptome analysis
Background in drug discovery workflows
Benefits
Health and wellness programs (including medical, dental, vision, life, and disability insurance)
Fitness centers
401(k) company match
Family support benefits
Equity awards
Annual bonuses
Paid time off
Paid leaves (e.g., military and parental leave)
Company
Regeneron
Regeneron Pharmaceuticals specializes in the discovery, development, and commercialization of innovative medicines.
10001+ employees
H1B Sponsorship
Regeneron has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (157)
2024 (128)
2023 (128)
2022 (137)
2021 (104)
2020 (122)
Funding
Current Stage
Public CompanyTotal Funding
$15.93MKey Investors
U.S. Department of Health & Human Services
2024-07-11Post Ipo Equity· $2.03M
2023-10-18Post Ipo Equity· $5M
2016-08-22Post Ipo Equity· $8.9M
Leadership Team
Aris Baras
Senior Vice President, Regeneron Pharmaceuticals, General Manager, Regeneron Genetics Center
Bari Kowal
Senior Vice President, Head Development Operations & Portfolio Management
Recent News
Pharmaceutical Technology
2026-01-16
2026-01-16
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