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Flagship Pioneering · 2 months ago

Associate Scientist/Scientist I, Biochemistry Screening & Biophysical Characterization

Boston, MA USA

Full-time

Onsite

New Grad, Entry, Mid Level

$96K/yr - $126K/yr

0+ years exp

Abiologics, Inc. is a privately held, early-stage biotechnology company focused on innovative therapeutic modalities. The role involves designing, developing, and executing biochemical and biophysical strategies to optimize Synteins, requiring collaboration with various scientific disciplines.

FinanceFinancial ServicesVenture Capital

H1B Sponsor Likely

Responsibilities

Design, develop, and validate robust biochemical and biophysical assays for hit identification, hit triage, and lead optimization across diverse target classes (enzymes, PPIs, receptors, and challenging targets)

Execute and analyze small- to medium-scale screens including development of counterscreens and artifact mitigation strategies

Perform quantitative biophysical characterization of ligand-target interactions, including affinity, kinetics, stoichiometry, and thermodynamics

Apply a range of techniques such as SPR/BLI, fluorescence-based assays, and mass-spectrometry based assays; leverage orthogonal methods to confirm binding and establish MOA

Ensure data quality and rigor through appropriate controls, reference standards, Z’ factor assessments, and comprehensive data QC and troubleshooting

Miniaturize and automate assays as appropriate; partner with automation/HTS teams and operate plate readers and liquid handling platforms

Analyze, visualize, and interpret complex datasets; summarize findings and recommend next steps to project teams

Proactively evaluate new technologies and methods to improve throughput, sensitivity, or mechanistic insight

Maintain accurate electronic lab notebooks, author SOPs, and present results to cross-functional stakeholders

Qualification

Biochemical assay developmentBiophysical characterizationBinding kineticsSPR/BLI proficiencyMass-spectrometry assaysCommunicationCollaboration skills

Required

PhD in Biochemistry, Biophysics, Chemical Biology, or related field with 0–1+ year of relevant experience; or MS with 6+ years; or BS with 8+ years in industry or equivalent

Demonstrated, hands-on experience developing and running biochemical and/or biophysical assays to quantify ligand binding and target engagement

Proficiency with core biophysical platforms (preferably BLI/SPR) and biochemical readouts (e.g., FP, TR-FRET/HTRF, AlphaLISA, enzymatic kinetics)

Track record of troubleshooting complex assay and protein reagent issues and delivering decision-enabling data on tight timelines

Excellent communication and collaboration skills; ability to work effectively in cross-functional, fast-paced environments

Benefits

Healthcare coverage

Annual incentive program

Retirement benefits

Broad range of other benefits

Company

Flagship Pioneering

Glassdoor3.3

Flagship Pioneering is a venture capital firm that invests in life sciences and healthcare companies.

Founded in 2000

Cambridge, Massachusetts, USA

501-1000 employees

http://flagshippioneering.com

H1B Sponsorship

Flagship Pioneering has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)

Distribution of Different Job Fields Receiving Sponsorship

Represents job field similar to this job

Trends of Total Sponsorships

2025 (8)

2024 (4)

2023 (4)

2022 (4)

2021 (1)