Abiologics · 2 months ago
Associate Scientist/Scientist I, Biochemistry Screening & Biophysical Characterization
Boston, MA
Full-time
Onsite
New Grad, Entry, Mid Level
0+ years expAbiologics, Inc. is a privately held biotechnology company focused on innovative therapeutic modalities. The role involves designing, developing, and executing biochemical and biophysical strategies for the discovery and optimization of Synteins, requiring collaboration with various scientific disciplines.
BiotechnologyLife ScienceMedical
Responsibilities
Design, develop, and validate robust biochemical and biophysical assays for hit identification, hit triage, and lead optimization across diverse target classes (enzymes, PPIs, receptors, and challenging targets)
Execute and analyze small- to medium-scale screens including development of counterscreens and artifact mitigation strategies
Perform quantitative biophysical characterization of ligand-target interactions, including affinity, kinetics, stoichiometry, and thermodynamics
Apply a range of techniques such as SPR/BLI, fluorescence-based assays, and mass-spectrometry based assays; leverage orthogonal methods to confirm binding and establish MOA
Ensure data quality and rigor through appropriate controls, reference standards, Z’ factor assessments, and comprehensive data QC and troubleshooting
Miniaturize and automate assays as appropriate; partner with automation/HTS teams and operate plate readers and liquid handling platforms
Analyze, visualize, and interpret complex datasets; summarize findings and recommend next steps to project teams
Proactively evaluate new technologies and methods to improve throughput, sensitivity, or mechanistic insight
Maintain accurate electronic lab notebooks, author SOPs, and present results to cross-functional stakeholders
Qualification
Required
PhD in Biochemistry, Biophysics, Chemical Biology, or related field with 0–1+ year of relevant experience; or MS with 6+ years; or BS with 8+ years in industry or equivalent
Demonstrated, hands-on experience developing and running biochemical and/or biophysical assays to quantify ligand binding and target engagement
Proficiency with core biophysical platforms (preferably BLI/SPR) and biochemical readouts (e.g., FP, TR-FRET/HTRF, AlphaLISA, enzymatic kinetics)
Track record of troubleshooting complex assay and protein reagent issues and delivering decision-enabling data on tight timelines
Excellent communication and collaboration skills; ability to work effectively in cross-functional, fast-paced environments
Company
Abiologics
Abiologics develops Synteins™ using AI and chemistry for new biologics.
11-50 employees
Funding
Current Stage
Early StageCompany data provided by crunchbase