Obsidian Therapeutics · 2 weeks ago
Senior Scientist/Principal Scientist, Analytical Development
Bedford, MA
Full-time
Onsite
Senior Level, Lead/Staff
$144K/yr - $202K/yr
5+ years expObsidian Therapeutics is pioneering engineered cell and gene therapies to deliver transformative outcomes for patients. They are seeking a highly motivated Senior or Principal Scientist to join their Analytical Development team, responsible for leading critical workstreams to enhance analytical capabilities for TIL products and viral vectors in support of their clinical pipeline.
BiotechnologyHealth CarePharmaceutical
Responsibilities
Drive internal and external TIL process characterization studies to enhance TIL product understanding
Design, plan, and execute experiments in Analytical Development, working both independently and as part of a multidisciplinary team of researchers
Support ongoing vector characterization at the Central Test Lab as the SME
Interpret results, troubleshoot technical hurdles, and propose solutions to the team
Maintain excellent records of experiments, including Electronic Notebook entries
Author and review technical and scientific documents including but not limited to study protocols and reports, validation documents, SOPs, and test methods
Act as a subject matter expert to represent the analytical development function as needed for regulatory interaction and author relevant CMC sections in regulatory documents
Collaborate effectively across Obsidian organization and CDMOs/CTLs, present internally to project teams, management, and scientific teams
Provide technical support to internal and external analytical operations
Qualification
Required
PhD in a relevant discipline (molecular biology, immunology, biochemistry, cell biology, virology or related field) with a minimum of 5+ years relevant industry experience including prior direct experience in retroviral and/ or lentiviral vector and cell therapies development with a progressive track record of leadership and impact
A track record in analytical development supporting late-stage development of cell therapy and/or biologics
Expertise in product characterization methods relevant to immune cell function (including cell-based potency assays, biomarker expression and function; ELISA, MSD, and flow cytometry)
Demonstrated knowledge of retro-viral vector characterization using molecular techniques (titration assays, PCR / qPCR, ddPCR, sequencing)
Experience working with CDMOs/ CTLs for method transfer/development/qualification/ validation and method life cycle management
Strong working knowledge of cGMP and quality systems requirements
Prior experience managing functional teams and external CDMO partners
Experience with multi-parameter flow cytometry assays, cell line/ primary cell transduction/ transfection
Excellent oral and written communication skills
Self-motivation, with a proven ability to manage multiple responsibilities in parallel with minimal direction
Scientific rigor in designing and executing experiments and record keeping
Flexibility - you adapt to change in a fast paced, rapidly developing environment
A Collaborative and accountable workstyle – you recognize that success requires teamwork and interdisciplinary thinking; you share feedback and ideas to facilitate better outcomes
Curiosity and humility – you seek and welcome input/expertise of others; you're a continuous learner
Tenacity and resilience – you're not easily overwhelmed by challenges, and deliver on commitments
Benefits
Annual incentive bonus as a percentage of actual base salary
Long-term incentives in the form of employee stock options
Comprehensive medical, dental, and vision coverage
Company contributions to health savings and retirement accounts
Ample paid time off
Access to wellness programs
Rich career growth opportunities
Company
Obsidian Therapeutics
Obsidian Therapeutics is a developer of a next-generation cell and gene therapies created to extend adoptive immunotherapy.
51-200 employees
H1B Sponsorship
Obsidian Therapeutics has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (3)
2023 (3)
2022 (2)
2021 (1)
Funding
Current Stage
Growth StageTotal Funding
$325MKey Investors
Wellington ManagementThe Column GroupGoogle Ventures
2024-04-03Series C· $160.5M
2021-09-09Series B· $115M
2017-12-06Series A· $49.5M
Leadership Team
Madan Jagasia
Chief Executive Officer
Kirsten Kester
Senior Vice President, Business Development
Recent News
DelveInsight Business Research LLP
2025-10-14
2025-10-09
Company data provided by crunchbase