Alnylam Pharmaceuticals · 2 days ago
Associate Director, Computational Genomics and Informatics
Cambridge, MA
Full-time
Hybrid
Lead/Staff, Director/Executive
$169K/yr - $238K/yr
8+ years expAlnylam Pharmaceuticals is a leader in RNAi therapeutics, and they are seeking an Associate Director to lead their Computational Genomics and Informatics capability. The role involves optimizing infrastructure for genetic data analysis, building genomic pipelines, and collaborating with various teams to enhance data accessibility and resource utilization.
BiotechnologyHealth CareMedicalPharmaceuticalTherapeutics
Hiring Manager
Jeannine Ripley
Responsibilities
Optimize our internal infrastructure and capabilities for analyzing individual-level genetic data and performing meta-analysis across biobanks. This includes managing partnerships with service providers to co-design analysis solutions
Build and implement genomics pipelines on external cloud-based platforms (e.g. DNA Nexus, All of Us Researcher workbench) to allow us to efficiently perform GWAS and RVAS
Design and implement solutions for harmonization and meta-analysis of GWAS and RVAS summary statistics, and efficient post-GWAS analysis. Build a framework to ensure these results are easily searchable and accessible
Monitor usage and costs to optimize resource utilization in both internal and external computing environments
Qualification
Required
PhD in Bioinformatics, Computer Science, Statistical Genetics or a related field with 8+ years of relevant experience in Computational Biology or a similar field. Title is commensurate with experience
Deep understanding of statistical genetics including GWAS and RVAS methods and extensive experience implementing statistical packages used for GWAS (e.g., Regenie, PLINK)
Extensive experience working with biobank-scale genetic and phenotypic data
Proven track record implementing genomics workflows on cloud-based platforms such as DNA Nexus, All of Us Researcher Workbench
Hands-on experience building portable pipelines across cloud environments using workflow languages (e.g., CWL, WDL, Nextflow) and software containerization
Experience with processing and QC of individual-level genetic data (WGS, WES, imputed). Experience with tools for genetic data processing (e.g., VCFtools) and variant annotation (VEP/WGSA)
Experience working on a Linux command line and advanced hands-on knowledge of Python and R
Familiarity with variant-to-gene post-GWAS methods (statistical fine mapping, colocalization, Mendelian Randomization)
Preferred
Proficiency in implementing web-based tools for genomics (dashboards, Shiny applications, PheWeb) would be an advantage
Benefits
Comprehensive benefits including medical, dental, and vision coverage
Life and disability insurance
A lifestyle reimbursement program
Flexible spending and health savings accounts
401(k) with a generous company match
Paid time off
Wellness days
Holidays
Two company-wide recharge breaks
Generous family resources and leave
Company
Alnylam Pharmaceuticals
Alnylam Pharmaceuticals is a biopharmaceutical company focused on the discovery, development and commercialization.
1001-5000 employees
H1B Sponsorship
Alnylam Pharmaceuticals has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2022 (18)
2021 (19)
2020 (7)
Funding
Current Stage
Public CompanyTotal Funding
$4.55BKey Investors
Blackstone Life SciencesBlackstone CreditRegeneron
2025-09-09Post Ipo Debt· $661.25M
2022-09-12Post Ipo Debt· $900M
2022-03-04IPO
Leadership Team
Yvonne Greenstreet
Chief Executive Officer
Jeff Poulton
Chief Financial Officer
Recent News
2025-12-22
2025-12-20
Company data provided by crunchbase