Prolific Machines · 2 months ago
Bioprocess Development - Senior Bioprocess Engineer/Scientist
Emeryville, CA
Full-time
Onsite
Senior Level
$135K/yr - $175K/yr
5+ years expProlific Machines is a biotechnology company focused on making next-generation therapies widely available. They are seeking a Senior Bioprocess Engineer/Scientist to lead the development of high titer processes for their mammalian cell lines and optimize antibody production processes while collaborating with various stakeholders across the company.
BiotechnologyHealth CareLife ScienceMachine LearningManufacturingTherapeutics
Responsibilities
Lead development of high titer processes and evaluate innovative technologies and solutions
Design and development of CHO cell culture process starting from clonal handoff to production scale bioreactors
Design and execute experiments at benchtop scale to determine optimal process parameters as well as process optimization to establish robust and scalable cell culture processes for various mammalian cell types
Serve as an organizational subject matter expert in CHO cell culture processes and bioreactor scale-up
Ensure technologies are in place to improve process efficiency and productivity. Work with the BPD team to expand capabilities and productivity
Collaborate with cell line development, bioprocess engineering and product development teams for the cross-functional coordination to make key decisions on tech transfers and technical support
Communicate with third-parties, suppliers and partners for ingredients, equipment, and novel approaches to process development and bioreactor technology
Qualification
Required
Advanced degree (MS or PhD preferred, BS acceptable with equivalent experience) with 5+ years of experience in technical development in a biopharmaceutical or similar industry
Extensive experience in CHO cell culture development with strong technical understanding of cell culture processes, scale-up principles, and optimization techniques
Experience with process development from both an early stage and late stage perspective. Experience with benchtop scales (250ml - 10L) is a must, experience with larger scales (50L - 1KL) is a plus
Strong understanding/experience in experimental design including design of experiment (DOE) and subsequent data analysis through SIMCA, JMP, or Python
Excellent verbal and written communication skills with clarity in communication around the tradeoffs in scope, quality, time and (human) resources
Understanding of CHO cell biology, cell line engineering and development
Preferred
Experience with single use bioreactors is a plus
Benefits
Generous equity package in an early stage company
Retirement plan with company contribution
Flexible PTO with healthy time off minimums
Company-covered medical, dental, and vision insurance
Life and disability insurance
Career coaching
Mental health support
Free team lunches everyday
Great snacks
Companywide social events
Company
Prolific Machines
Prolific Machines unlocks production of next-generation therapeutics with a light-controlled gene expression system and closed-loop control.
11-50 employees
H1B Sponsorship
Prolific Machines has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2024 (1)
2022 (1)
2021 (1)
Funding
Current Stage
Growth StageTotal Funding
$97MKey Investors
Ki Tua FundBreakthrough Energy Ventures
2024-06-06Series B· $55M
2022-12-07Convertible Note
2022-09-14Series A· $42M
Leadership Team
Declan Jones
Co-Founder & CIO
Recent News
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