Revance · 3 hours ago
Quality Control Manager
Johnson City, TN
Contract
Onsite
Senior Level
7+ years expRevance is a fast-growing global aesthetics and skincare company focused on providing innovative aesthetics and market-leading skincare offerings throughout every stage of life. The Quality Control Manager provides scientific leadership and technical oversight for all analytical operations supporting Pharmaceutical, Over-the-Counter, and Cosmetic products, ensuring laboratory compliance and driving process improvements.
BiotechnologyHealth CarePharmaceuticalTherapeutics
Responsibilities
Lead, mentor, and develop QC Supervisors, Chemists, and Analysts through structured training and technical coaching
Maintain current training matrices, instrument qualifications, and competency assessments
Support succession planning, performance evaluations, and individual development plans
Promote a culture of scientific excellence, ownership, and regulatory compliance
Lead and schedule all QC testing activities for raw materials, in-process, finished goods, and stability samples
Ensure testing is performed per validated or verified methods (HPLC, GC, UV-Vis, FTIR, ICP-OES/MS, KF, TOC, pH, viscosity, etc.)
Review and approve analytical data, chromatographic integrations, system suitability results, and trend analyses in accordance with ALCOA+ principles
Manage daily priorities to support batch release, stability commitments, and regulatory submissions
Support product investigations, method transfers, and laboratory deviation resolution
Maintain full compliance with cGMP, ICH, USP, EP, and MoCRA standards
Implement data-integrity governance across OpenLab CDS, iStability, and electronic record systems (audit trails, user access, instrument logbooks)
Ensure accuracy, contemporaneous documentation, and traceability for all analytical activities
Author and maintain laboratory SOPs, validation protocols, and technical reports
Act as QC representative during internal, corporate, and FDA inspections, ensuring readiness and timely response to observations
Oversee method validation, verification, and transfer activities following ICH Q2(R2)
Evaluate method robustness, linearity, accuracy, precision, and detection limits; author and review validation summary reports
Manage raw material qualification and release under 21 CFR 211.84, approving supplier CoAs and verification results
Develop risk-based sampling and testing plans for excipients, APIs, and packaging components
Maintain method equivalency and harmonization across contract and sister-site laboratories
Administer the site stability program per ICH Q1A–Q1F, including pull scheduling, testing, and reporting
Review trend charts, regression analyses, and control charts to identify OOT behavior before specification limits are breached
Author or review stability summary reports, OOS/OOT investigations, and risk assessments supporting expiry dating
Ensure timely reporting and electronic data archiving per retention policy
Oversee qualification, calibration, and PM of analytical instruments (HPLC/UPLC, GC, FTIR, ICP-MS/OES, UV-Vis, KF, balances, ovens)
Maintain validated status of computerized systems under 21 CFR Part 11 and Annex 11
Support CAPEX planning, URS/FAT/SAT/IOQ/PQ execution, and implementation of new technologies (e.g., autosamplers, LIMS integration)
Approve equipment change controls and ensure adherence to life-cycle validation protocols
Own and manage OOS, OOT, Deviation, NCM, CAPA, and Change Control processes
Participate in Quality Review Boards, CAPA Effectiveness Reviews, and Risk Assessments (FMEA, 5-Why, Fishbone)
Develop and monitor Key Performance Indicators (KPIs) such as Right-First-Time, CAPA timeliness, and laboratory cycle time
Lead continuous-improvement initiatives focused on method robustness, cycle-time reduction, and Cost of Quality (CoQ) optimization
Qualification
Required
Bachelor's degree & 7+ years' directly related experience
Preferred
Bachelor's degree in Chemistry, Biochemistry, Pharmaceutical Sciences, or related field
Advanced degree
7-10 years in a cGMP QC laboratory; minimum 3-5 years in management or supervision
Hands-on experience in method validation, stability programs, analytical troubleshooting, and regulatory audits
Proven knowledge of FDA, ICH, USP/NF, and MoCRA regulatory frameworks
Benefits
Competitive Compensation including base salary and annual performance bonus.
Flexible PTO, holidays, and parental leave.
Generous healthcare benefits, HSA match, 401k match, employer paid life and disability insurance, pet insurance, wellness discounts and much more!
Company
Revance
We believe that science-powered innovation creates possibilities.
1001-5000 employees
H1B Sponsorship
Revance has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (8)
2024 (16)
2023 (8)
2022 (10)
2021 (16)
2020 (3)
Funding
Current Stage
Public CompanyTotal Funding
$1.68BKey Investors
Athyrium Capital Management LPEssex Woodlands Healthcare PartnersMedicis Pharmaceutical
2024-08-12Acquired
2024-03-04Post Ipo Equity· $100M
2022-09-12Post Ipo Equity· $200M
Leadership Team
Nadeem Moiz
Chief Executive Officer
Recent News
MarketScreener
2025-10-27
Company data provided by crunchbase