AbbVie · 8 hours ago
Senior Scientist II - Modeling and Simulation
Irvine, CA
Full-time
Onsite
Mid, Senior Level
4+ years expAbbVie is a company dedicated to discovering and delivering innovative medicines and solutions that address serious health issues. The Senior Scientist II - Modeling and Simulation will contribute expertise in pharmacokinetics and modeling to support drug development efforts, particularly in the areas of ophthalmology and aesthetics/dermatology.
BiotechnologyFinancial ServicesHealth CareMedicalPharmaceuticalVenture Capital
Responsibilities
Apply PK and PK/PD modeling/simulation to guide the design and execution of in vivo preclinical animal experiments and/or early-stage clinical trials
Identify opportunities to apply and develop modeling and simulation strategies across the R&D portfolio, with a focus on ophthalmology and aesthetics/dermatology
Integrate M&S knowledge to contribute to optimizing translational sciences strategies
Analysis of PK/PD data, both clinical and nonclinical, through the use of sophisticated mathematical and statistical modeling and simulation tools to support dose selection, study design and proof-of-concept
Identify and monitor vendors and consultants or engage internal resources as appropriate to meet project deliverables
In collaboration with other stakeholders, conduct and integrate data analyses and summarize modeling outcomes to support IND, CTA, IMPD, NDA, and BLA filing and regulatory correspondences
Exploratory analyses and non-conventional modeling beyond systemic drug development with a focus on locally-administered/acting products
Maintain awareness of current technologies in PK/PD and PBPK modeling
Develop close and effective partnerships with other nonclinical and clinical pharmacology/PKPD and biomarker scientists, safety scientists, research scientists, clinicians and project teams
Design and provide scientific oversight of preclinical PK/TK studies
At project level, establish and maintain effective collaborations with key stakeholders to facilitate data integration for biomarker selection, candidate nomination/selection, and human dose prediction
May mentor/supervise a team of one or more and guide and evaluate the performance of those individuals; is accountable for the effective performance of the team/individuals
Qualification
Required
Bachelor's Degree and typically 12 years of experience OR Master's Degree and typically 10 years of experience OR PhD and typically 4 years of experience in Pharmaceutical Sciences, Quantitative Pharmacology, Biomedical/Chemical Engineering, Pharmacometrics or related field
2+ years of experience in PK/PD modeling & simulation, quantitative pharmacology, and/or applied population PK in the pharmaceutical industry
Ability to work onsite based out of our Irvine, CA location
Academic and/or industry experience in either physiologically-based pharmacokinetic (PBPK) modeling or population PK/PKPD modeling
Strong knowledge of biology (mechanism of action)/pharmacology, clinical immunology, protein sciences, statistics, and pharmaceutical development
Ability to learn new areas of biological sciences and build on solid foundation of quantitative skills to develop models
Data manipulation and programming skills and ideally with the use of programs such as SAS, R, S+ or similar programs
Experience using Phoenix WNL, GastroPlus, and SimCyp
Scientific publications in area of specialization
Effective written and verbal communication skills
Strong ability to collaborate with others
Ability to keep up-to-date with and propose the implementation of scientific and technological developments in the area of modeling
The successful candidate is required to have ability to work within a diverse workforce
Preferred
Experience with biologics including gene therapy
Experience with general programming and data analysis tools/languages such as R, Matlab, Berkeley Madonna, ADAPT, etc
Benefits
Paid time off (vacation, holidays, sick)
Medical/dental/vision insurance
401(k)
Short-term incentive programs
Company
AbbVie
AbbVie is a biopharmaceutical company focused on immunology, oncology, neuroscience, virology, and aesthetics. It is a sub-organization of AbbVie.
10001+ employees
H1B Sponsorship
AbbVie has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (273)
2024 (190)
2023 (225)
2022 (284)
2021 (186)
2020 (186)
Funding
Current Stage
Public CompanyTotal Funding
$15B2024-02-27Post Ipo Debt· $15B
2023-03-08Post Ipo Equity· $0.25M
2012-12-20IPO
Leadership Team
Robert Michael
Chairman of the Board and Chief Executive Officer
Micah Bregman
Vice President, Global Strategy and Pipeline, Allergan Aesthetics
Recent News
2026-01-14
2026-01-14
Company data provided by crunchbase