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Madrigal Pharmaceuticals · 3 weeks ago

Senior Director, SOX Compliance

Waltham, MA

Full-time

Hybrid

Director/Executive

$245K/yr - $299K/yr

15+ years exp

Madrigal Pharmaceuticals is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH). They are seeking a Senior Director, SOX Compliance to lead the company’s enterprise-wide Sarbanes-Oxley (SOX) program, ensuring compliance and enhancing internal controls while collaborating across various functions.

BiopharmaBiotechnologyMedical DevicePharmaceutical

Responsibilities

Maintain and enhance Madrigal’s SOX compliance program, including scoping, risk assessment, control design, documentation, testing, remediation, and ongoing monitoring

Partner with Finance, IT, Legal, HR, and business operations to ensure controls are properly designed and operating effectively across all key processes and systems

Lead the annual SOX risk assessment and control initiatives to ensure compliance efforts are efficient and aligned with business priorities

Lead annual internal and external process walkthroughs

Manage relationships with external auditors and consultants to ensure timely coordination of SOX testing and reporting

Drive continuous improvement of SOX-related processes, automation opportunities, and control environment maturity

Lead RFP and implementation process for SOX software

Serve as the primary point of contact for SOX matters across the organization, including executive management and the Audit Committee

Communicate control deficiencies, testing results, and remediation progress in a clear, actionable manner to senior leadership

Partner closely with Finance and IT leadership to ensure alignment between control requirements, system implementations, and process changes

Provide strategic insight and guidance on internal control implications of new business initiatives, system implementations, and policy changes

Monitor evolving regulatory expectations, PCAOB standards, and best practices in internal control frameworks (e.g., COSO 2013) to ensure Madrigal remains compliant and forward-looking

Evaluate emerging risks and operational changes that could impact the control environment, proposing proactive mitigations where appropriate

Promote a strong control culture throughout the organization by training and mentoring control owners and stakeholders

Qualification

SOX complianceInternal controlsRisk managementPCAOB standardsCOSO frameworksIT general controlsLeadership skillsStakeholder alignmentCommunication skillsMentoringCollaboration

Required

Bachelor's degree in Accounting, Finance, or related field; CPA or CIA required

15+ years of progressive experience Finance with 5+ years in SOX compliance, internal controls, and risk management — ideally including both public accounting and corporate experience in the biotech or pharmaceutical industry

Proven success building or transforming a SOX function within a complex, global organization

Deep knowledge of SOX 404 compliance, COSO frameworks, internal controls, and PCAOB standards

Strong understanding of IT general controls (ITGCs), automated controls, and system implementation risk

Exceptional communication and leadership skills with the ability to influence and align stakeholders across all levels of the organization

Demonstrated ability to build and mentor a high-performing team and effectively manage external partners

Willingness to travel up to ~10% (domestic and international)