Treeline · 19 hours ago
Senior Director, Clinical Pharmacology
Watertown, Massachusetts, United States
Full-time
Onsite
Director/Executive
$248K/yr - $320K/yr
10+ years expTreeline Biosciences is seeking a Senior Director of Clinical Pharmacology to lead the design and execution of clinical pharmacology programs. This role involves overseeing studies that support clinical trials and collaborating with various teams to ensure the integrity of pharmacokinetic and pharmacodynamic analyses for regulatory submissions.
BiotechnologyHealth CareLife ScienceMedicalPrecision Medicine
Responsibilities
Lead the design, implementation, and execution of clinical pharmacology strategies across Treeline’s portfolio to support IND, first-in-human, proof-of-concept, and registrational studies
Develop, execute and convey to Treeline leadership clinical pharmacology plans, including PK/PD modeling, dose selection, and exposure–response analyses, and population pharmacokinetic analysis
Oversee collection, processing, and analysis of patient samples across all clinical programs to ensure data quality and scientific integrity
Partner with Drug Metabolism and Pharmacokinetics, Translational Medicine, Toxicology, and Biomarkers teams to design and interpret clinical studies supporting mechanism of action, safety, and efficacy
Provide scientific and operational oversight for bioanalytical assay development, validation, and sample testing conducted at internal and external laboratories
Ensure high-quality data ingestion and integration of pharmacology and biomarker datasets to support clinical decision-making and regulatory submissions
Represent Clinical Pharmacology in cross-functional program teams, contributing to protocol design, statistical analysis plans, and regulatory documentation
Lead preparation of key sections of clinical study reports, investigator brochures, and regulatory filings (IND, NDA, BLA)
Provide scientific input and defend clinical pharmacology strategies in interactions with regulatory authorities
Qualification
Required
PhD, PharmD, or MD in Pharmacology, Pharmaceutical Sciences, or a related discipline
10+ years of clinical pharmacology experience in the biotech or pharmaceutical industry, including leadership roles in clinical-stage development
Demonstrated expertise in clinical pharmacology strategy, study design, and regulatory interactions from early development through registration
Deep understanding of PopPK, PK/PD principles, modeling and simulation, and exposure–response analysis
Proven experience overseeing patient sample management, bioanalytical testing, and assay validation
Strong cross-functional leadership and ability to integrate complex scientific data into strategic development decisions
Excellent communication skills, with the ability to present to senior leadership and external stakeholders
Preferred
Oncology experience strongly preferred
Company
Treeline
Treeline (or Treeline Biosciences) is a privately held, clinical-stage biopharma company that aspires to make medicines at the highest level.
51-200 employees
H1B Sponsorship
Treeline has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (1)
2024 (4)
2023 (3)
2021 (1)
Funding
Current Stage
Growth StageTotal Funding
$1.09BKey Investors
AI Life Sciences Investments LLCKohlberg Kravis Roberts
2025-09-03Series A· $200M
2024-10-17Undisclosed· $421M
2022-10-11Series A· $261.27M
Leadership Team
Spencer Smith
Chief Financial Officer
Recent News
2025-10-04
2025-10-01
Genetic Engineering News
2025-09-30
Company data provided by crunchbase