CRISPR Therapeutics · 3 days ago
Senior/ Principal Scientist, LNP Analytics
Boston, MA
Full-time
Onsite
Senior Level, Lead/Staff
$147K/yr - $160K/yr
5+ years expCRISPR Therapeutics is a pioneering company in gene editing with a diverse portfolio of product candidates. They are seeking a highly motivated Senior Scientist/Principal Scientist to join their Analytical Development team focused on LNP delivered in vivo therapeutics, contributing to method development and ensuring regulatory compliance.
BiopharmaBiotechnologyGeneticsMedical
Responsibilities
Hands-on development, execution and troubleshooting of analytical assays to characterize and quantify LNPs and related materials
Design, perform, and provide guidance for method development, optimization, troubleshooting, feasibility, transfer, qualification of analytical methods for internal and external stakeholders
Spearhead the evaluation and adoption of new technologies and new analytical methods
Serve as a technical lead and subject matter expert (SME) for analytical projects at CMOs/CROs ensuring scientific rigor and regulatory compliance
Provide analytical expertise for comparability studies to support manufacturing process changes and product lifecycle management
Author and review SOPs, analytical protocols, technical reports, and regulatory submission documents (e.g., IND, BLA)
Apply a range of biochemical and biophysical analytical techniques including FFF-MALS, nFCM, NTA, CE, Chromatography, Mass Photometry, etc. relevant to LNP DS and DP
Interpret and present complex analytical data with clarity to internal stakeholders and regulatory agencies
Mentor and/or supervise junior scientists, providing guidance on experimental design, troubleshooting, and career development
Collaborate cross-functionally with Research, Process Development, Quality, and Regulatory teams to support program advancement from early development and preclinical through clinical and commercial stages
Foster a culture of resilience, collaboration, and entrepreneurial thinking
Qualification
Required
PhD in Biochemistry, Molecular Biology, Analytical Chemistry, or related discipline with Senior Scientist: 5+ years of relevant industry experience, or non-PhD and 12+ years progressive, relevant experience
Proven expertise in developing, troubleshooting, and executing assays for LNP or related products
Strong understanding of in vivo gene therapy delivery platforms
Advanced analytical and data analysis skills
Experience working with external laboratories (CMOs/CROs) for method development and stage-appropriate validations
Understanding of regulatory and compendial expectations (e.g., ICH, USP/Eur.Ph.) for mRNA and for analytical methods
Excellent written and verbal communication skills
Ability to work independently and collaboratively in a dynamic, matrixed environment
Scientific curiosity and creativity
Preferred
Prior experience with analytical support for regulatory filings (e.g., IND, IMPD, BLA)
Familiarity with platform analytical approaches for mRNA therapeutics and LNP-formulated Cell and Gene Therapy products
Experience with liquid handler platforms and method automation
Demonstrated ability to lead cross-functional initiatives or technical teams
Passion for science, high level of integrity, and a proactive mindset aligned with core values of collaboration, undaunted spirit, resilience, and entrepreneurship
Benefits
Bonus
Equity
Benefits
Company
CRISPR Therapeutics
CRISPR Therapeutics is focused on the development of transformative medicines using its proprietary CRISPR/Cas9 gene-editing platform.
201-500 employees
H1B Sponsorship
CRISPR Therapeutics has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (18)
2024 (25)
2023 (16)
2022 (18)
2021 (13)
2020 (16)
Funding
Current Stage
Public CompanyTotal Funding
$407MKey Investors
EcoR1 CapitalBill & Melinda Gates FoundationVersant Ventures
2024-02-13Post Ipo Equity· $280M
2020-12-14Grant
2016-10-19IPO
Leadership Team
Raju Prasad
Chief Financial Officer
Naimish Patel
Chief Medical Officer
Recent News
MarketScreener
2026-01-03
2025-12-26
2025-12-26
Company data provided by crunchbase