Research Lab Tech Lead jobs in United States
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Mass General Brigham · 2 months ago

Research Lab Tech Lead

positionBoston-MA
timeFull-time
remoteOnsite
senioritySenior Level
money$62K/yr - $91K/yr

Mass General Brigham is a not-for-profit organization focused on patient care, research, teaching, and community service. They are seeking an experienced Research Technologist to lead their noninvasive fetal sequencing project, responsible for optimizing protocols and validating results against current diagnostic standards.

Health CareHome Health CareMedical
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H1B Sponsor Likelynote

Responsibilities

Perform DNA/RNA extraction from blood samples (incl. whole blood, buffy coat, plasma)
Perform other molecular genomics procedures as needed (i.e., sequencing library production, target hybridization, RNAseq, sample archiving, tissue culture, etc.)
Learn and perform any number of molecular genomics techniques, including single-cell RNAseq (scRNAseq), ATACseq, ChIPseq, HiC, and other methods
Independently performs non-routine, highly specialized experimental procedures
Participates in the design and modification of research protocols
Develops research methodologies within the parameters of experimental protocols and research objectives
Composes and may present sections of research reports and manuscripts
Performs advanced data analysis using advanced statistical techniques
Responsible for the oversight and coordination of lab activities, including quality assurance
Responsible for the oversight and coordination of the scheduling of all procedures
Responsible for troubleshooting problems and instructing others in highly specialized techniques

Qualification

Next-generation sequencing (NGS)CfDNA extractionMolecular genomics techniquesSanger sequencingPCRQPCR assaysSample trackingQuality controlData analysisResearch protocol design

Required

Experience or high capacity to learn handling of human blood-derived samples, including isolation of plasma and buffy coat under sterile and reproducible conditions
Experience or high capacity to learn sample processing, labeling, and biobanking under rigorous quality control and contamination-prevention measures consistent with good laboratory practice (GLP) standards
Experience or high capacity to learn extraction and robust handling of cell-free DNA (cfDNA) and genomic DNA (gDNA) from plasma, blood, and human tissues
Experience or high capacity to learn next-generation sequencing (NGS) library preparation for low-input cfDNA/gDNA samples and target hybridization protocols for exome and custom sequencing panels
Experience or high capacity to learn Sanger sequencing, gel electrophoresis, PCR, and qPCR-based assays for cfDNA quantification, variant detection, and workflow validation
Experience or high capacity to learn NGS library quality control and assessment, including quantification and fragment size analysis
Experience or high capacity to learn accurate sample tracking and documentation across all stages of processing and analysis
Perform DNA/RNA extraction from blood samples (incl. whole blood, buffy coat, plasma)
Perform other molecular genomics procedures as needed (i.e., sequencing library production, target hybridization, RNAseq, sample archiving, tissue culture, etc.)
Learn and perform any number of molecular genomics techniques, including single-cell RNAseq (scRNAseq), ATACseq, ChIPseq, HiC, and other methods
Independently perform non-routine, highly specialized experimental procedures
Participate in the design and modification of research protocols
Develop research methodologies within the parameters of experimental protocols and research objectives
Compose and may present sections of research reports and manuscripts
Perform advanced data analysis using advanced statistical techniques
Responsible for the oversight and coordination of lab activities, including quality assurance
Responsible for the oversight and coordination of the scheduling of all procedures
Responsible for troubleshooting problems and instructing others in highly specialized techniques

Benefits

Comprehensive benefits
Career advancement opportunities
Differentials
Premiums
Bonuses
Recognition programs designed to celebrate your contributions and support your professional growth

Company

Mass General Brigham

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Mass General Brigham specializes in providing medical treatments and health diagnostics services.
dateFounded in 1994
location
Somerville, Massachusetts, USA
people-size10001+ employees
web-link
https://www.massgeneralbrigham.org

H1B Sponsorship

Mass General Brigham has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (77)
2024 (61)
2023 (93)
2022 (70)
2021 (80)
2020 (29)

Funding

Current Stage
Late Stage

Leadership Team

E
Erin Flanigan
SVP, Human Resources, Community, Specialty Hospital Division
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O’Neil A. Britton
Chief Integration Officer, Executive Vice President
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