Apply on Employer Site

Bluestem Biosciences, Inc. · 2 months ago

Scientist, Enzyme Engineering

Omaha, NE

Full-time

Onsite

Mid, Senior Level

3+ years exp

Bluestem Biosciences is a company focused on using American corn to produce critical chemicals domestically. They are seeking a motivated Scientist to design and analyze enzyme engineering libraries to enhance industrial chemical production.

AgTechBiotechnologyChemicalLife ScienceRenewable Energy

Responsibilities

Bring your enzyme library design toolkit to Bluestem to head up enzyme improvement approaches

Create clever screening or selection strategies to find the improvements within the enzyme diversity you’ve designed (e.g., activity, stability, selectivity)

Manage external experiments by working closely with our network of contract research organizations (CROs) to ensure successful execution and high-quality data delivery

Find the signal in the noise! Analyze and interpret large datasets from high-throughput enzyme screens and implement iterative improvements

Coordinate closely with the broader Bluestem R&D team on project outcomes, and share the commercial impact of your work with the whole company

Transfer optimized enzymes and protocols to the strain engineering team for integration into production hosts

Have an impact outside your domain expertise and contribute to the Bluestem R&D effort, taking an “end-in-mind” approach to building our success

Qualification

Protein EngineeringEnzyme EngineeringComputational BiologyHigh-throughput ScreeningData AnalysisProject ManagementPythonRJMPAttention to DetailOrganizational SkillsTime ManagementCollaborationCommunication

Required

Ph.D. in Protein Engineering, Enzyme Engineering, Computational Biology, Biochemistry, Bioengineering, or a related scientific field, and 3+ years of hands-on industry experience

Demonstrated proficiency in modern protein and enzyme engineering techniques, including both computation approaches (e.g., AlphaFold, AI/ML-based design methods) and library design (e.g., directed evolution, rational design, saturation mutagenesis)

Experience managing workflows and projects with external partners or contract research organizations (CROs) is highly preferred

Familiarity with high-throughput screening (HTS) methods, enzyme activity assays, analytical methodologies, and selection-based screens

Exceptional attention to detail and the ability to successfully design complex experiments and analyze large-scale screening data

Strong organizational and time-management skills. Ability to work independently with minimal supervision while contributing to a collaborative team environment

Ability to effectively organize and analyze results and data (using Python, R, or JMP) and communicate results to the extended team