Alnylam Pharmaceuticals · 1 day ago
Senior Associate Scientist, Oncology Research - In Vivo
Cambridge, MA
Full-time
Onsite
Mid, Senior Level
$76K/yr - $114K/yr
3+ years expAlnylam Pharmaceuticals is a leader in RNAi therapeutics, dedicated to transforming lives through innovative science. They are seeking a highly motivated Senior Associate Scientist to join their Oncology Research team, focusing on developing RNAi therapeutics against cancer through in vivo experiments and collaboration within an interdisciplinary team.
BiotechnologyHealth CareMedicalPharmaceuticalTherapeutics
Responsibilities
Engage in investigative RNAi research evaluating siRNA delivery and efficacy to diverse oncology animal models
Develop and perform in vivo and ex vivo studies using molecular and biochemical techniques to characterize distribution and activity of a variety of siRNAs
Routine tasks would include cancer cell line culture, in vivo efficacy, and PK/PD studies as well as processing harvested tissue for ex vivo analyses
Analyze and interpret data and communicate results to the team
Collaborate with team members to progress drug discovery efforts, contributing to a dynamic, exciting culture that embraces teamwork, innovation, and transparency
Qualification
Required
BS or MS in Animal/Veterinary Sciences, Cell/Molecular Biology, Biochemistry, or related field
3-5 years of research experience in industry conducting in vivo pharmacology studies using mouse tumor models is essential
Expertise in mouse handling, dosing, subcutaneous and orthotopic tumor implantation, and tissue harvesting and collection
Experience working with syngeneic and immune-compromised mice required
Direct experience monitoring tumor growth using IVIS or Lago and software analysis required
Proficiency in multiple dosing routes i.e. IP, IV, SC, intratumoral and blood collection (RO or submandibular) required
Experience in tumor cell line tissue culture required
Ability to follow SOPs, execute, analyze, interpret, and troubleshoot experiments
Excellent lab technique and the ability to work independently
Good documentation of all experimental procedures and results in an ELN
Excellent communicator, team-oriented, and able to handle multiple different projects/experiments at once
Preferred
Stereotaxic procedures, intrathecal (IT), and intracerebroventricular (ICV) dosing in mice a plus
Experience in molecular biology techniques including RNA/DNA/protein extraction, qPCR, Western blot, ELISA a plus
Basic understanding of standard cancer therapeutics and immuno-oncology a plus
Experience using Prism, IVIS or Lago software analysis, Excel required
Benefits
Comprehensive benefits including medical, dental, and vision coverage
Life and disability insurance
A lifestyle reimbursement program
Flexible spending and health savings accounts
A 401(k) with a generous company match
Paid time off
Wellness days
Holidays
Two company-wide recharge breaks
Generous family resources and leave
Company
Alnylam Pharmaceuticals
Alnylam Pharmaceuticals is a biopharmaceutical company focused on the discovery, development and commercialization.
1001-5000 employees
H1B Sponsorship
Alnylam Pharmaceuticals has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2022 (18)
2021 (19)
2020 (7)
Funding
Current Stage
Public CompanyTotal Funding
$4.55BKey Investors
Blackstone Life SciencesBlackstone CreditRegeneron
2025-09-09Post Ipo Debt· $661.25M
2022-09-12Post Ipo Debt· $900M
2022-03-04IPO
Leadership Team
Yvonne Greenstreet
Chief Executive Officer
Jeff Poulton
Chief Financial Officer
Recent News
2025-12-22
2025-12-20
Company data provided by crunchbase