Kymera Therapeutics · 7 hours ago
Scientist II or Senior Scientist, Targeted Proteomics
Greater Boston
Full-time
Onsite
Mid, Senior Level
$90K/yr - $200K/yr
2+ years expKymera Therapeutics is a clinical-stage biotechnology company pioneering the field of targeted protein degradation to develop innovative medicines. The Scientist II or Senior Scientist in Targeted Proteomics will develop and implement proteomics analysis workflows that support drug discovery and development, collaborating cross-functionally to ensure high-quality results.
BiotechnologyHealth CareMedicalTherapeutics
Responsibilities
Develop, optimize, and implement targeted proteomics analysis workflows, including automated enrichment strategies, to deliver precise, accurate, and sensitive protein measurements that inform drug discovery and development decisions
Collaborate cross-functionally to implement and qualify assays that drive pipeline decision-making
Communicate proactively with project teams and within the proteomics function to coordinate sample availability, align timelines, and ensure timely delivery of high-quality results
Manage and oversee activities at contract research organizations (CROs), including assay transfer, qualification, and performance monitoring, ensuring adherence to project specifications, timelines, and data quality standards
Perform targeted protein mass spectrometry (MS) assays using state-of-the-art LC-MS systems—including nano-LC and Orbitrap platforms—to determine pharmacodynamic (PD) effects, quantify biomarkers, and qualify assays for clinical studies
Prepare samples from a wide variety of biological matrices (cultured cells, tissues, plasma, biofluids) from both human and preclinical species using manual and automated bead-based workflows
Perform and interpret quantitative proteomics data analyses using software such as Skyline, MaxQuant, DIANN, and Spectronaut; generate clear, data-driven reports for cross-functional stakeholders
Maintain, qualify, and troubleshoot HPLC and MS instrument performance to ensure reliability and reproducibility
Present scientific results and strategic recommendations to internal project teams, senior leadership, and external collaborators in a clear, concise, and influential manner
Qualification
Required
PhD in Biochemistry, Biology, Chemistry, or Chemical Biology with a minimum of 2 years of experience in targeted, mass spectrometry–based proteomics in an industry or startup biotech setting; or BS/MS with 8+ years of relevant experience
Broad expertise in targeted proteomics, including:
Development and deployment of highly multiplexed and sensitive PRM or MRM stable isotope–labeled peptide assays using DDA and DIA data
Development of immunoaffinity enrichment methods to enhance MS sensitivity
Optimization of protein recovery from complex biological matrices (cells, tissues, plasma, biofluids) and various sample formulations (fresh, frozen, FFPE) across preclinical species
Operation, maintenance, and troubleshooting of nanoLC and Orbitrap MS instrumentation
Quantitative analysis and report generation using Skyline and related proteomics data tools
Demonstrated ability to independently analyze, interpret, and clearly communicate targeted proteomics data and conclusions to multidisciplinary teams
Proven success collaborating across functional areas and managing CRO relationships to deliver qualified assays that support drug discovery and clinical development
Strong organizational, problem-solving, and time-management skills with the ability to prioritize multiple projects to meet TPD drug discovery timelines
Excellent written and verbal communication skills, with the ability to convey complex scientific concepts to both technical and non-technical audiences
Preferred
Familiarity with regulatory filings (e.g., IND) and qualification of MS assays for clinical applications
Working knowledge of automated sample processing, including immunoaffinity capture MS assays
Benefits
Eligibility for annual bonus
Equity participation
Comprehensive benefits
Company
Kymera Therapeutics
Kymera Therapeutics is a biotechnology company that specializes in the field of targeted protein degradation.
51-200 employees
H1B Sponsorship
Kymera Therapeutics has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (5)
2024 (2)
2023 (4)
2022 (3)
2021 (3)
Funding
Current Stage
Public CompanyTotal Funding
$1.96BKey Investors
Biotechnology Value FundAtlas Venture
2025-12-10Post Ipo Equity· $602M
2025-06-26Post Ipo Equity· $250.8M
2024-08-19Post Ipo Equity· $225M
Leadership Team
Nello Mainolfi
Founder, President and Chief Executive Officer
Jeremy Chadwick
Chief Operating Officer
Recent News
2026-01-16
2026-01-11
Company data provided by crunchbase