Eli Lilly and Company · 16 hours ago
Scientist/Sr Scientist - Oligonucleotide Analytics
Indianapolis, IN
Full-time
Onsite
Mid, Senior Level
$65K/yr - $169K/yr
5+ years expEli Lilly and Company is a global healthcare leader headquartered in Indianapolis, Indiana, focused on discovering and delivering life-changing medicines. The LIGM RNA Group is seeking an experienced scientist to perform analytical characterization and development of oligonucleotides, utilizing advanced techniques such as LCMS.
BiotechnologyHealth CareMedicalPharmaceutical
Responsibilities
Perform sample preparation for forced degradation and solution stability studies to support developability evaluation at the candidate selection stage for oligonucleotides and their conjugates, including carbohydrates, lipids, small molecules, and others
Characterize the solubility, and physical and chemical stability of drug candidates and formulations using various analytical techniques, including but not limited to chromatography, mass spectrometry, microscopy, thermal analysis, dynamic light scattering, pharmaceutical particle counting, and backgrounded membrane imaging
Design and develop LC/LCMS-based methods to elucidate impurities and degradants from API and stability samples
Partner with the Early Phase TIDES team and the drug discovery team to identify appropriate analytical data packages to support method and project transfers as needed
Identify and mitigate technical risks affecting the performance and production of drug candidates
Demonstrate exceptional teamwork and learning agility to solve complex technical problems and to identify and implement novel formulations based on drug delivery technologies that enhance patient benefit and add value to Lilly
Collaborate with, inspire, and influence the external scientific community to drive innovation, foster collaborations, and strengthen Lilly's internal portfolio
Continuously refine and improve existing analytical methods and assays, and innovate as necessary to meet evolving program needs
Rapidly assimilate new technologies and apply cross-disciplinary scientific concepts to address complex analytical challenges
Maintain thorough, accurate, and timely documentation of experiments, protocols, and results in electronic laboratory notebooks and technical reports
Ensure high standards of laboratory practice, including compliance with safety and quality guidelines, and promote operational excellence in all analytical activities
Communicate findings and progress effectively, including regular presentations in project team, department, and governance meetings
Qualification
Required
M.S. in Chemistry, Analytical Chemistry, Biophysics, Biochemistry, or a related field with at least 5 years of experience in analytical characterization using LC/LCMS, OR a B.S. in Chemistry, Analytical Chemistry, Biophysics, Biochemistry, or a related field with at least 8 years of relevant analytical characterization experience using LC/LCMS
Extensive hands-on experience in the analytical characterization and development of oligonucleotides and their conjugates, primarily using LCMS instruments
Proven track record with liquid chromatography, mass spectrometry, and other advanced analytical techniques
Strong technical problem-solving skills and the ability to quickly learn and apply new technologies or explore new fields
Ability to work independently while delivering high-quality, efficient results in a fast-paced environment
Exceptional teamwork and learning agility to solve complex technical problems
Ability to identify and implement novel formulations based on drug delivery technologies
Ability to maintain thorough, accurate, and timely documentation of experiments, protocols, and results in electronic laboratory notebooks and technical reports
High standards of laboratory practice, including compliance with safety and quality guidelines
Effective communication of findings and progress, including regular presentations in project team, department, and governance meetings
Preferred
Strong understanding of biopharmaceutics and pharmacokinetic principles, phase-appropriate formulation development and analytical characterization, pharmaceutical material sciences, and drug product factors that impact in vivo performance and manufacturing
Demonstrated experience in scale-up sample preparation and analytical characterization of oligonucleotides and their conjugates, as well as biologics
Proficiency in biophysical and analytical characterization techniques, including but not limited to light scattering methods, chromatography, mass spectrometry, backgrounded membrane imaging, and other molecular-level characterization tools
Experience in separation sciences, including but not limited to RP, HILIC, HIC, IEX, SEC, and CE
Expertise in mass spectrometry, including ESI ionization with a range of instrument platforms (QToF, Orbitrap, QQQ)
Experience with analytical development on oligonucleotides and their conjugates
Strong teamwork, communication, and scientific writing skills
Benefits
Company-sponsored 401(k)
Pension
Vacation benefits
Eligibility for medical, dental, vision and prescription drug benefits
Flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts)
Life insurance and death benefits
Certain time off and leave of absence benefits
Well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities)
Company
Eli Lilly and Company
We're a medicine company turning science into healing to make life better for people around the world.
10001+ employees
H1B Sponsorship
Eli Lilly and Company has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
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Trends of Total Sponsorships
2025 (514)
2024 (236)
2023 (167)
2022 (133)
2021 (57)
2020 (52)
Funding
Current Stage
Public CompanyTotal Funding
$6.5M2024-02-12Post Ipo Debt· $6.5M
1978-01-13IPO
Leadership Team
David Ricks
Chair, CEO
Lucas Montarce
Executive Vice President and Chief Financial Officer
Recent News
2026-01-16
2026-01-16
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