United Therapeutics Corporation · 3 hours ago
Scientist – Matrix Biology
Triangle Area
Full-time
Onsite
Senior Level
5+ years expUnited Therapeutics Corporation is a pioneering biotech company focused on developing novel pharmaceutical therapies and technologies for organ transplantation. The Scientist in Matrix Biology will contribute to the advancement of engineered lung development by characterizing matrix components, analyzing recellularization outcomes, and optimizing scaffold stability for pulmonary function assessments.
BiotechnologyPharmaceuticalTherapeutics
Hiring Manager
Samantha Jill Olinger, SPHR, SHRM-SCP, PRC, CDR, CSMR
Responsibilities
Characterize the stability of matrix components, identify relevant degradation profiles, and mitigate degradation of key components, as appropriate
Identify potential process changes or storage conditions to mitigate stability concerns, and contribute to the evaluation and implementation of changes to process or storage conditions
Analyze recellularization outcomes to understand the role of the ECM scaffold in the biology of regeneration in engineered lung constructs
Evaluate and optimize scaffold ECM stability from decellularization through recellularization and terminal pulmonary function assessments
Determine the proper chemical conditions for ECM stability, ECM component supplementation and adsorption, and ECM-cell interactions
Analyze matrix composition, turnover, and cell-derived matrix deposition in engineered tissues, interpret these findings, and provide insightful and actionable methods to improve or stabilize the function of the engineered tissues which may include supplementation with bioactive matrix or matrix-associated molecules
Assess the mechanical function of the scaffold at the organ (pulmonary mechanics) and tissue (interstitial, alveolar, and microvascular integrity) levels and develop methods to promote the proper organization and function of the matrix molecules to achieve optimal regeneration of native organ function
Evaluate the consistency of findings between in vitro assays and large-scale recellularization studies, adjusting or developing new assays as necessary
Independently integrate analyses from experiments across multiple sub-teams to determine key factors which drive outcomes, as needed
Develop new techniques, laboratory procedures, and/or protocols to support lung scaffold recellularization and characterization efforts, as needed
Proficiently perform complex scientific tasks and independently make complex technical or scientific decisions
Proficiently analyze data, potentially utilizing sophisticated or in-depth analyses, and through such analyses, identify novel data trends
Evaluate new technologies or methods, applying scientific insights to the process. Coordinate tech transfer with academic & industrial collaborators
Develop and implement novel, impactful, and/or complex experimental plans. Generate insightful complex hypotheses and conclusions. Apply scientific knowledge and literature evidence to experimental planning
Prepare and present regular reports on research strategy and progress
Independently contribute to focused research areas through maintenance and continued development of knowledge using past and current scientific literature as well as collaborative thinking
Commit to supporting individual, group, and departmental goals to achieve key objectives
Appropriately document performance and methods
Help maintain smooth operations of the lab, including maintaining lab supplies, monitoring equipment and providing lab support
Perform other duties as assigned
Qualification
Required
Masters degree with 6+ years of related industry or academic faculty-level experience or a PhD with 2+ years of related industry or academic faculty-level experience
5+ years of experience and comfort developing, optimizing, and performing analytical assays, evaluating and interpreting data, and optimizing and troubleshooting analytical assays
Experience includes proficiency with at least 4 of the following analytical tools in support of research efforts: histology, immunohistochemistry, image analysis, SEM/TEM, biochemistry, ELISA, Western Blot, and/or proteomics/glycomics, mechanical testing
Experience with statistical analysis utilizing JMP, GraphPad Prism, R or other comparable program
Proficiency and experience developing, optimizing, and performing analytical assays, evaluating and interpreting data, and optimizing and troubleshooting analytical assays
Proficient in applying Design of Experiments (DOE) principles and advanced statistical methods for experimental planning and data interpretation
Familiarity with material and device biocompatibility evaluation and associated regulatory requirements
Preferred
Doctor of Philosophy (PhD) in protein/cell biology, biomaterials, biotechnology, biomedical engineering, biomechanics, or related field
Performs and interprets results of uniaxial mechanical testing
Experience with MatLab and/or Python
Comparative Proteomic Quantitation/Comparative Analysis Program(s)
Previous regenerative medicine or tissue engineering experience involving cellular and matrix or scaffold interactions
Experience/knowledge in one or more of the following: - Mechanical characterization of biomaterials, Chemical modifications of extracellular matrix, - Immunological techniques (IHC, ELISA), - Accelerated degradation study of biomaterials, product or prototype characterization of proteins, and/or - Protein detection, western blot or ELISA especially as applied to ECM component or degradative products
Contribution to regulatory filing(s) in support of clinical candidate development
Benefits
Medical / dental / vision / prescription coverage
Employee wellness resources
Savings plans (401k and ESPP)
Paid time off & paid parental leave benefits
Disability benefits
More
Company
United Therapeutics Corporation
Founded to find a cure for a daughter’s rare disease, United Therapeutics is a biotechnology company transforming care for people with chronic and life-threatening conditions.
1001-5000 employees
H1B Sponsorship
United Therapeutics Corporation has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (9)
2024 (13)
2023 (8)
2022 (6)
2021 (9)
2020 (4)
Funding
Current Stage
Public CompanyTotal Funding
unknown1999-06-17IPO
Leadership Team
Hamlet Bonilla Evertsz
Senior Network Engineer
Recent News
2025-12-29
NH Business Review
2025-11-11
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