Lead Bioinformatics Scientist, NGS jobs in United States
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Profluent · 2 months ago

Lead Bioinformatics Scientist, NGS

positionEmeryville, California, United States
timeFull-time
remoteOnsite
senioritySenior Level, Lead/Staff
money$160K/yr - $230K/yr
date5+ years exp

Profluent is an AI-first protein design company that develops deep generative models to design and validate novel, functional proteins to revolutionize biomedicine. They are seeking an experienced computational scientist to lead the design, development, and operation of the NGS analysis platform that supports gene editing and protein design programs.

Artificial Intelligence (AI)BiotechnologyLife Science
badNo H1Bnote

Responsibilities

Lead design and implementation of scalable NGS analysis pipelines supporting gene editing and protein engineering workflows
Develop clear, intuitive visualizations and reports to communicate sequencing results and biological insights
Manage cloud-based compute environments and data systems for large-scale datasets
Partner with biology teams to analyze results, troubleshoot, and optimize experimental design
Collaborate with machine learning teams to curate data for model training
Establish best practices for code review, testing, and CI/CD in computational workflows
Mentor junior scientists and foster a culture of rigor, reproducibility, and innovation

Qualification

NGS data analysisPython programmingWorkflow orchestrationCloud environmentsContainerizationLinux expertiseGit version controlGene editing technologiesSQL familiarityLIMS platformsScientific software development

Required

PhD or MS in Bioinformatics, Computational Biology, Computer Science, or a related quantitative field
5+ years of experience analyzing NGS datasets (e.g., amplicon sequencing, high-throughput editing, or screening experiments)
Strong programming skills in Python (pandas, numpy, biopython, etc.)
Expertise with workflow orchestration tools (Nextflow, Snakemake) and cloud environments (GCP, AWS)
Experience with containerization (Docker, Kubernetes) and scalable compute infrastructure
Deep understanding of Linux, git-based version control, and software engineering best practices
Proven ability to transform complex sequencing data into actionable biological insights

Preferred

Experience with gene editing technologies (CRISPR, base or prime editing; strongly preferred)
Familiarity with SQL and data modeling for biological or experimental data
Experience with LIMS platforms (e.g., Benchling) and lab data integration
Track record of developing production-quality scientific software or open-source bioinformatics tools

Benefits

Comprehensive benefits including health/dental/vision insurance
Generous PTO policy and commitment to work-life balance
Professional development opportunities in a cutting-edge field at the intersection of AI and biology

Company

Profluent

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Profluent is an AI-first protein design company.
dateFounded in 2022
location
Berkeley, California, USA
people-size11-50 employees
web-link
https://www.profluent.bio/

Funding

Current Stage
Growth Stage
Total Funding
$150M
Key Investors
Spark CapitalInsight Partners
2025-11-19Series B· $106M
2024-03-21Series Unknown· $35M
2022-08-25Seed· $9M

Leadership Team

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Ali Madani
Founder
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Recent News

globallegalchronicle.com
Profluent Secures $106 Million to Advance AI-Driven Protein Design
2025-11-24
SiliconANGLE
AI wars: Microsoft pitches the agent superstore, Google models ace tests and OpenAI looks over its shoulder
2025-11-22
Business Wire
Profluent Raises $106M to Scale Frontier AI Models for Programmable Biology
2025-11-20
Company data provided by crunchbase