Eli Lilly and Company · 21 hours ago
Principal Scientist/Sr. Principal Scientist - Bioconjugation Process Development
Indianapolis, IN
Full-time
Onsite
Senior Level, Lead/Staff
$65K/yr - $169K/yr
3+ years expEli Lilly and Company is a global healthcare leader headquartered in Indianapolis, Indiana, focused on discovering and delivering life-changing medicines. The role involves establishing the infrastructure for bioconjugation process development, collaborating with teams to conduct research, and advancing bioconjugate medicines for clinical trials and commercialization.
BiotechnologyHealth CareMedicalPharmaceutical
Responsibilities
Establish a productive laboratory program by directly designing and executing internal research plans, collaborate with teammates to analyze the results, form conclusions, propose logical next steps, and report findings to a larger team
Learn and apply new skills such as bioconjugation, purification screening, OFAT and Design of Experiment methodology, and analytical sample analysis
Operate at the interface between disciplines and departments to quickly move from one scientific challenge to another while navigating ambiguity
Perform fundamental and detailed studies of each process step for bioconjugation development
Perform scale-up demonstrations of bioconjugation processes and purifications to provide material and information for development purposes
Propose and test new methods to achieve bioconjugation and bioconjugate development. Collaborate and share findings with partners
Strong oral and written communication skills are expected
Perform necessary documentation work such as electronic notebook maintenance, report authoring and regulatory/manufacturing documentation
Bring new and useful concepts, methods, and ideas for how research can be improved and share these to make our group better
Demonstrate learning agility across modalities (e.g. small molecule, peptide and oligonucleotide)
Help formulate commercial manufacturing strategy and collaborate with manufacturing partners to deliver robust processes that are ultimately suitable for large-scale production
Qualification
Required
BS with 6+ years of relevant experience or Master's degree with 3+ years of relevant experience in synthetic organic chemistry, biochemistry, chemical biology, chemical engineering or related field
Experience with synthetic organic chemistry or biochemistry
Strong oral and written communication skills
Ability to prioritize multiple activities and thrive in a setting that requires quick movement between scientific challenges and comfort with ambiguity
Preferred
Experience with small molecule organic synthesis, knowledge of reaction mechanisms, and design of reactions
Experience with performing bioconjugation reactions at small-scale
Knowledge of basic antibody class, structure, and function
Knowledge of and hands-on experience with analytical methods used for small molecules and biomolecules (RP-HPLC, SEC, IEX, HIC, LC-MS, CE-SDS)
Good interpersonal skills and a persistent tendency for collaboration
Demonstrated self-initiative and appropriate risk-taking behaviors
An active scientific curiosity and interest in complementary disciplines within the pharmaceutical industry
Hands-on experience with liquid chromatography: bioconjugate purification and familiarity with chromatography systems
Benefits
Company bonus
Eligibility to participate in a company-sponsored 401(k)
Pension
Vacation benefits
Eligibility for medical, dental, vision and prescription drug benefits
Flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts)
Life insurance and death benefits
Certain time off and leave of absence benefits
Well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities)
Company
Eli Lilly and Company
We're a medicine company turning science into healing to make life better for people around the world.
10001+ employees
H1B Sponsorship
Eli Lilly and Company has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (404)
2024 (236)
2023 (167)
2022 (133)
2021 (57)
2020 (52)
Funding
Current Stage
Public CompanyTotal Funding
$6.5M2024-02-12Post Ipo Debt· $6.5M
1978-01-13IPO
Leadership Team
David Ricks
Chair, CEO
Lucas Montarce
Executive Vice President and Chief Financial Officer
Recent News
2025-12-30
2025-12-30
Company data provided by crunchbase