Eli Lilly and Company · 1 month ago
TSMS Lab Sr. Principal Process Scientist
US, Lebanon IN
Full-time
Onsite
Senior Level, Lead/Staff
$66K/yr - $172K/yr
3+ years expEli Lilly and Company is seeking a highly motivated and skilled TSMS Lab Sr. Principal Process Scientist to join our dynamic team. This role focuses on the development, optimization, and scale-up of peptide synthesis and/or purification processes. Additionally, this role will be critical in advancing our peptide-based therapeutic pipeline through commercialization, ensuring robust, efficient, and scalable manufacturing processes.
BiotechnologyHealth CareMedicalPharmaceutical
Responsibilities
Lead and execute laboratory-based research and development activities for the synthesis and/or purification of complex peptides, including solid-phase peptide synthesis (SPPS) and solution-phase peptide synthesis (LPPS)
Design and perform experiments for process optimization, including reaction conditions, reagent selection, purification strategies (e.g., HPLC, preparative chromatography), and yield improvement
Troubleshoot and resolve technical challenges related to peptide synthesis and/or purification, applying a deep understanding of organic chemistry and peptide chemistry principles
Collaborate cross-functionally with medicinal chemists, analytical chemists, process engineers, and manufacturing teams to ensure seamless technology transfer and scale-up of peptide processes
Document experimental procedures, results, and conclusions thoroughly in laboratory notebooks and technical reports
Present findings and recommendations to project teams and senior management
Stay abreast of the latest scientific advancements in peptide chemistry, synthesis technologies, and purification techniques
Contribute to the development of intellectual property and patent applications
Adhere to all safety regulations and good laboratory practices (GLP)
Qualification
Required
Ph.D. in Organic Chemistry, Medicinal Chemistry, Chemical Engineering, or a related scientific discipline with a strong emphasis on peptide synthesis and purification
Minimum of 3 years of relevant experience in peptide process development within a pharmaceutical or biotechnology setting (post-doctoral experience will be considered)
Demonstrated expertise in both solid-phase and solution-phase peptide synthesis techniques
Proficiency in various preparative chromatography techniques, particularly HPLC and MPLC for peptide purification
Strong understanding of analytical techniques used for peptide characterization (LC-MS, NMR, UV-Vis, AAA, etc.)
Excellent problem-solving skills and a strong ability to work independently and as part of a team
Outstanding written and verbal communication skills, with the ability to present complex scientific information clearly and concisely
Preferred
Experience with process scale-up and technology transfer to manufacturing is highly desirable
Familiarity with cGMP principles and quality systems is a plus
Benefits
Company bonus
Company-sponsored 401(k)
Pension
Vacation benefits
Medical, dental, vision and prescription drug benefits
Flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts)
Life insurance and death benefits
Certain time off and leave of absence benefits
Well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities)
Company
Eli Lilly and Company
We're a medicine company turning science into healing to make life better for people around the world.
10001+ employees
H1B Sponsorship
Eli Lilly and Company has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
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Trends of Total Sponsorships
2025 (514)
2024 (236)
2023 (167)
2022 (133)
2021 (57)
2020 (52)
Funding
Current Stage
Public CompanyTotal Funding
$6.5M2024-02-12Post Ipo Debt· $6.5M
1978-01-13IPO
Leadership Team
David Ricks
Chair, CEO
Lucas Montarce
Executive Vice President and Chief Financial Officer
Recent News
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