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Empirico · 1 month ago

Scientist - CMC

Madison, WI

Full-time

Onsite

Mid, Senior Level

$90K/yr - $120K/yr

3+ years exp

Empirico is a clinical-stage biotechnology company focused on siRNA medicines. They are seeking a chemist to support the synthesis and characterization of oligonucleotides, with responsibilities including process development and technology transfer to CDMOs.

BiotechnologyLife ScienceMedical

No H1B

Responsibilities

Perform solid-phase synthesis, purification, and characterization of oligonucleotides

Develop and optimize scalable upstream (synthesis) and downstream (purification, formulation) manufacturing processes

Support process development activities to enable successful technology transfer to CDMOs

Analyze, interpret, and clearly communicate synthetic and analytical data

Present findings to senior staff and cross-functional teams

Troubleshoot and refine synthesis and purification protocols

Manage multiple projects simultaneously

Qualification

Solid-phase oligonucleotide synthesisAnalytical chemistryProcess developmentCGMP environment experienceAnalytical instrumentationMethod developmentCommunication skillsProject management

Required

BS in Chemistry with at least 7 years of relevant industry experience, or an MS in Organic Chemistry, Biochemistry, or Chemical Engineering with a minimum of 3 years of experience, or a PhD with at least 1 year of relevant experience

Minimum 1 year of experience working in a cGMP environment

Hands-on proficiency with analytical instrumentation such as NMR, LC-MS, and RP-HPLC

1–7 years of relevant work experience, preferably in solid-phase oligonucleotide synthesis, and familiarity with both upstream and downstream oligonucleotide manufacturing processes

Demonstrated ability in analytical and purification method development using RPIP-HPLC, AEX-HPLC, UV, MALDI, and HRMS

Background in process development and technology transfer to CDMOs, including development of scalable purification and formulation methodologies

Working knowledge of tangential flow filtration (TFF) method development

Applicants must have authorization to work in the U.S