Eli Lilly and Company · 1 day ago
Sr. Director, ADC Drug-Linker Synthetic Process Development
Indianapolis, IN
Full-time
Onsite
Director/Executive
$159K/yr - $233K/yr
8+ years expEli Lilly and Company is a global healthcare leader headquartered in Indianapolis, Indiana, focused on discovering and delivering life-changing medicines. They are seeking a highly experienced Senior Director to lead payload linker development efforts within the Antibody-Drug Conjugate (ADC) team, focusing on the design, optimization, and scaling of payload linker chemistry critical to next-generation ADC therapeutics.
BiotechnologyHealth CareMedicalPharmaceutical
Responsibilities
Lead and oversee CMC process development activities for novel payloads and drug-linkers within ADC programs, ensuring alignment with overall program goals
Collaborate closely with Discovery teams to ensure manufacturability and facilitate smooth transition from early research to CMC development
Develop scalable, robust, and reproducible processes for payload linker synthesis, enabling seamless technology transfer from development labs to GMP manufacturing
Build and strengthen internal capabilities by developing team expertise, infrastructure, and technologies related to payload linker process development
Stay current of emerging technologies and scientific advancements in ADC linker and payload chemistry to maintain competitive edge
Champion a strong safety culture in all laboratory activities, ensuring proper handling, containment, and risk assessment practices for highly potent compounds
Provide technical guidance and career development support to team members, including goal setting, performance evaluations, and skills enhancement
Manage external collaborations with vendors and CDMOs specializing in linker and payload synthesis and process development
Ensure compliance with regulatory guidelines and support filing activities for INDs, BLAs, and other regulatory submissions
Qualification
Required
Ph.D. in synthetic organic chemistry or relevant scientific discipline with > 8 years of experience; B.S. or M.S. with 15+ years of demonstrated equivalent experience in a related field of expertise
Proven leadership experience managing small molecule CMC development programs and leading scientific teams through all stages of development from discovery handoff to GMP manufacturing and regulatory submission
Extensive expertise and scientific knowledge in linker design, payload chemistry, and related bioconjugation strategies
Proven ability to drive innovation in ADC or small molecule process development, with a focus on implementing novel technologies, improving efficiency, and solving complex scientific challenges
Experience in preparing and contributing to regulatory filings, including IND, IMPD, and BLA submissions, with responsibility for drafting and reviewing CMC-related documentation
Preferred
Experience working in high-potency laboratory environments, including the development of containment strategies and implementation of occupational safety practices, is highly desirable
Experience working with ADC projects, especially regarding the unique CMC and regulatory considerations, is a plus
Strong leadership skills with a track record of building, mentoring, and retaining high-performing technical teams
Excellent cross-functional collaboration and communication skills; able to influence without authority and align internal and external stakeholders
Benefits
Company-sponsored 401(k)
Pension
Vacation benefits
Eligibility for medical, dental, vision and prescription drug benefits
Flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts)
Life insurance and death benefits
Certain time off and leave of absence benefits
Well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities)
Company
Eli Lilly and Company
We're a medicine company turning science into healing to make life better for people around the world.
10001+ employees
H1B Sponsorship
Eli Lilly and Company has a track record of offering H1B sponsorships. Please note that this does not
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reference. (Data Powered by US Department of Labor)
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2025 (514)
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2021 (57)
2020 (52)
Funding
Current Stage
Public CompanyTotal Funding
$6.5M2024-02-12Post Ipo Debt· $6.5M
1978-01-13IPO
Leadership Team
David Ricks
Chair, CEO
Lucas Montarce
Executive Vice President and Chief Financial Officer
Recent News
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