Madrigal Pharmaceuticals · 3 weeks ago
Associate Director, Global Health Economics and Outcomes Research
Springfield, Massachusetts Metropolitan Area
Full-time
Hybrid
Lead/Staff, Director/Executive
$179K/yr - $219K/yr
10+ years expMadrigal Pharmaceuticals is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH). The Associate Director, Global Health Economics & Outcomes Research will support strategic goals by providing evidence development to demonstrate the value of medicines for liver health, particularly for the medication Rezdiffra.
BiopharmaBiotechnologyMedical DevicePharmaceutical
Responsibilities
Analyze complex real-world data (RWD) sources such as administrative claims and electronic health records databases
Design, build, and maintain internal data warehouses
Develop and maintain reproducible analytical pipelines and real-world evidence (RWE) platforms using R programming, leveraging version control tools and collaborative coding environments (e.g., GitHub), while integrating SQL and Python where beneficial
Build and govern internal real-world data (RWD) analytics infrastructure by leveraging modern platforms such as Posit Workbench and Databricks to enable end-to-end RWE study execution
Execute both rapid analyses and full protocol-driven observational studies, ensuring methodologies are robust and scientifically sound
Leverage advanced analytic and statistical modeling techniques (e.g., Cox regression, propensity score matching, IPTW) to drive causal inference and integrate data across diverse real-world sources
Navigate complex datasets to leverage data that improves patient outcomes
Ensure RWE studies adhere to FDA and EMA regulatory guidance to produce high-quality evidence supporting label expansion and HTA submissions
Partner with cross-functional stakeholders—including regulatory, access, and data science teams—as needed to inform RWD analyses across the product lifecycle
Stay current on industry trends and advancements in RWE and HEOR methodologies
Present at scientific conferences and publish in key journals
Ensure all activities comply with company SOPs, industry standards, and applicable regulations
Uphold the highest ethical standards in all external engagements
Travel up to 30% for scientific congress attendance, internal and external meetings
Ability to work across global time zones as needed
Qualification
Required
Graduate degree in biostatistics, public health, epidemiology, or a similar field
10-12+ years of relevant experience
In-depth experience with R programming, version control and collaborative development tools (e.g., GitHub), and analytic environments such as Posit Workbench, Databricks or similar cloud-based data science platforms
Expertise in applying advanced statistical analytic methodologies to RWD
Familiarity with common commercially available RWD data assets encompassing administrative claims and EHR databases
Experience in delivering ad-hoc and full protocol-driven observational studies
Experience with liver / metabolic diseases in the RWD space would be preferred
A strong track record of publications
Strong communication skills
High proficiency with project management systems, Medical Affairs dashboards, CRM platforms, and enterprise collaboration tools (e.g., Veeva, Microsoft Office Suite, SharePoint, Teams, Zoom)
Preferred
PhD preferred
Experience with SQL and Python
In-depth knowledge of liver disease; experience in cardiometabolic health or metabolic dysfunction-associated steatohepatitis (MASH)
Benefits
Equity
Flexible paid time off
Medical
Dental
Vision and life/disability insurance
401(k) offerings (i.e., traditional, Roth, and employer match)
Supplemental life insurance
Legal services
Mental health benefits through our Employee Assistance Program for employees and their family
Company
Madrigal Pharmaceuticals
Madrigal Pharmaceuticals is a biopharmaceutical company developing therapeutics for the treatment of cardiovascular-metabolic diseases.
501-1000 employees
H1B Sponsorship
Madrigal Pharmaceuticals has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2022 (1)
Funding
Current Stage
Public CompanyTotal Funding
$1.94BKey Investors
Blue OwlHercules Capital
2025-07-22Post Ipo Debt· $350M
2024-03-18Post Ipo Equity· $690M
2023-09-28Post Ipo Equity· $500M
Leadership Team
Mardi C. Dier
Chief Financial Officer
Carole Huntsman
Chief Commercial Officer (CCO)
Recent News
Pharma Letter
2026-01-11
StreetInsider.com
2026-01-11
Company data provided by crunchbase