Asimov · 1 day ago
Senior Computational Biologist
Boston, MA
Full-time
Onsite
Mid, Senior Level
$150K/yr - $175K/yr
3+ years expAsimov is on a mission to advance humanity's ability to design living systems through biotechnologies. They are seeking a Senior Computational Biologist to develop and apply sophisticated models that integrate diverse biological data, focusing on optimizing therapeutic molecules and systems.
Artificial Intelligence (AI)BiotechnologySoftwareTherapeutics
Responsibilities
Design and implement sophisticated models—including data-driven (ML/AI), mechanistic (e.g., ODE-based), and hybrid approaches—to predict and optimize the performance of biologics and vector manufacturing processes
Develop models that predict functional outcomes such as transgene expressibility, protein stability, and product quality attributes from nucleic acid and amino acid sequence features
Develop new models to predict developability attributes such as expressibility, secretability, aggregation, and stability of biologics, from sequence
Create multi-scale models of cellular behavior, integrating omics data (RNA-seq, proteomics, etc.) to simulate gene expression, protein secretion dynamics, metabolism, and cell phenotype
Work in close collaboration with bench scientists to guide rational experimental design, using techniques like Bayesian Optimization to ensure that data generation is maximally informative for modeling and yields actionable insights
Contribute to our long-term computational strategy by exploring novel algorithms, modeling frameworks, and data integration techniques to solve critical challenges in synthetic biology and therapeutic development
Qualification
Required
Ph.D. in Bioengineering, Computational Biology, Computer Science, Applied Mathematics, or a related quantitative field
Proficient in sequence-based analysis and have hands-on experience integrating large-scale omics datasets (e.g., NGS, RNA-seq, proteomics) to inform model development and validation
Expert in applying machine learning and advanced mathematical techniques (e.g., dynamical systems, differential equations, stochastic modeling) to biological systems, with at least 3 years of experience in a pharmaceutical or biotechnology industry setting
Strong background in modeling dynamic biological systems, such as gene regulatory networks, metabolic pathways, or cell population dynamics
Skilled programmer, fluent in Python and associated scientific computing/ML libraries
Excel at communicating complex scientific and mathematical concepts effectively to colleagues with diverse backgrounds and expertise
Collaborative, impact-driven scientist, passionate about working in a fast-paced, research-focused environment to engineer biology
Company
Asimov
Asimov employs artificial intelligence to develop tools for the design and manufacture of next-generation therapeutics.
11-50 employees
H1B Sponsorship
Asimov has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (5)
2024 (2)
2023 (1)
2022 (2)
Funding
Current Stage
Growth StageTotal Funding
$205MKey Investors
CPP InvestmentsHorizons VenturesAndreessen Horowitz
2023-01-05Series B· $175M
2020-01-01Series A· $25M
2017-12-19Seed· $5M
Leadership Team
Alec Nielsen
Co-founder & CEO
Christopher Voigt
Co-Founder
Recent News
Precedence Research
2025-11-27
Company data provided by crunchbase