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Cabaletta Bio · 1 day ago

Vice President and Head of Information Technology

Philadelphia, PA

Full-time

Hybrid

Director/Executive

10+ years exp

Cabaletta Bio is a clinical-stage biotechnology company focused on developing curative targeted cell therapies for autoimmune diseases. The Vice President and Head of Information Technology will be responsible for designing and managing the company's IT infrastructure and strategy, ensuring compliance and operational excellence across all functions.

BiotechnologyHealth CareMedicalRoboticsTherapeutics

Responsibilities

Develop and execute a forward-looking IT strategy aligned with business priorities and regulatory requirements

Partner closely with executive leadership to identify and implement technology solutions that drive efficiency and innovation

Build and lead a high-performing IT team, fostering a culture of service, agility, and continuous improvement

Experience with building and integrating a global Cell and/or Gene product ordering platform across the patient journey in close partnership with relevant internal stakeholders

Architect and deploy scalable infrastructure across cloud, network, and on-premise environments

Collaborate with functional leads to guide the selection and implementation of reliable and efficient enterprise systems (e.g., ERP, LIMS, QMS, HRIS, CRM) to support scientific, clinical, technical operations, commercial and corporate functions

Ensure system interoperability, data integrity, and performance across the organization

Establish and maintain robust cybersecurity frameworks and data protection protocols

Ensure IT systems and practices comply with GxP, HIPAA, GDPR, and other relevant regulations, where applicable

Lead IT audits, risk assessments, and incident response planning, maintaining clear traceability

Provide responsive and proactive IT support to all departments, including R&D, clinical, regulatory, and finance

Prioritize investments based on value, risk, and life cycle phase in alignment with corporate strategy

Manage IT budgets, vendors, and service level agreements

Drive automation, analytics, and digital transformation, and AI initiatives to enhance productivity and scalability

Develop, engage, and collaborate in change management practices for updates and changes

Qualification

IT infrastructure managementCloud platforms AWSCloud platforms AzureCybersecurity frameworksRegulatory compliance GxPRegulatory compliance HIPAAEnterprise applicationsTeam leadershipClient-focused approachContinuous self-developmentCommunication skillsCross-functional collaboration

Required

Bachelor's or Master's degree in Computer Science, Information Systems, or related field

10+ years of progressive IT leadership experience, with at least 3 years in biotech, pharma, or life sciences

Proven success in building IT infrastructure and teams from the ground up in a high-growth environment with preference for direct experience in supporting autologous cell therapy launch and commercialization

Expertise in SaaS and cloud platforms (e.g., AWS, Azure), cybersecurity, and enterprise applications

Experience with GxP systems, 21 CFR Part 11, GAMP 5, EU Annex 9, ICH Q9 and other regulatory compliance systems in a commercial biotech or clinical setting

Strong leadership, communication, and cross-functional collaboration skills with a client focused, partnering approach

Strong team orientation and passion for continuous self-development