Eli Lilly and Company · 1 month ago
Principal Scientist - In-vitro Display
US, San Diego CA
Full-time
Onsite
Senior Level, Lead/Staff
$110K/yr - $187K/yr
6+ years expEli Lilly and Company is a global healthcare leader headquartered in Indianapolis, Indiana, focused on discovering and bringing life-changing medicines to those in need. The Principal Scientist will contribute to the discovery and development of biotherapeutics, working in a dynamic team environment and engaging in multiple work streams related to antibody discovery and characterization.
BiotechnologyHealth CareMedicalPharmaceutical
Responsibilities
Discover, engineer, and optimize antibodies using *in vitro* display technologies to improve biological function, developability, and immunogenicity profiles
Use biochemical and functional assays to evaluate antibody-antigen interaction including ELISA, cell binding and signaling assays, Octet or other SPR-based techniques
Demonstrate strong expertise in molecular and cellular biology techniques including western blotting, PCR, cell culture, and site-directed mutagenesis
Experience with antibody fusions, Fc-fusions, and conjugation to antibodies is highly desirable
Qualification
Required
B.S./M.S. in a relevant field with at least 6+ years industry experience in molecular biology, biochemistry, or protein engineering
Proven hands-on experience with fundamental biology techniques, including: cell culture, viability assays, transfections, Western blot, affinity assays, image-based assays
Strong experience in molecular biology including standard cloning techniques, sequence analysis, DNA and RNA extraction, ligation, PCR
Hands-on experience with flow cytometry
Experience in tissue culture
An understanding of biochemistry and molecular biology especially pertaining to techniques for protein engineering
Detail oriented, skilled at data analysis and troubleshooting
Accountable for preparing and presenting data at lab meetings with guidance regarding required tasks and expected results
Preferred
Experience with flow cytometry is highly desirable
An understanding of antibody discovery, particularly with respect to in vitro display systems
Excellent communication skills with a desire to be involved in collaborative, cross
Benefits
Company bonus (depending, in part, on company and individual performance)
Eligibility to participate in a company-sponsored 401(k)
Pension
Vacation benefits
Eligibility for medical, dental, vision and prescription drug benefits
Flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts)
Life insurance and death benefits
Certain time off and leave of absence benefits
Well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities)
Company
Eli Lilly and Company
We're a medicine company turning science into healing to make life better for people around the world.
10001+ employees
H1B Sponsorship
Eli Lilly and Company has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (514)
2024 (236)
2023 (167)
2022 (133)
2021 (57)
2020 (52)
Funding
Current Stage
Public CompanyTotal Funding
$6.5M2024-02-12Post Ipo Debt· $6.5M
1978-01-13IPO
Leadership Team
David Ricks
Chair, CEO
Lucas Montarce
Executive Vice President and Chief Financial Officer
Recent News
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2026-01-14
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2026-01-14
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