Volastra Therapeutics · 2 months ago
Scientist, Discovery Science
New York, NY
Full-time
Onsite
Senior Level
$130K/yr - $150K/yr
5+ years expVolastra Therapeutics, Inc. is a clinical-stage oncology biotech company based in New York City, pioneering novel approaches to treating cancer by targeting chromosomal instability. The Scientist of Discovery Science will design, execute, and interpret experiments to validate targets and accelerate progression from hit/lead to in vivo proof-of-concept, collaborating closely with the Discovery Team.
BiotechnologyLife ScienceMedical
Responsibilities
• Participate in key discovery workstreams from target validation through early pharmacology; design clear, decision‑driving experimental plans and timelines
• Interrogate mechanism using genetic perturbation (e.g. CRISPR/Cas9, RNAi), rescue, pathway mapping, and combination studies aligned with CIN biology
• Develop and optimize cellular assays to quantify phenotype and mechanism
• Build translationally relevant target‑engagement and PD assays to enable SAR and inform dose/PK–PD modeling for in vivo studies
• Track record of successfully managing external projects with CRO's from scoping to final data delivery
• Work effectively with colleagues across the team to participate in adjacent discovery-related efforts
• Provide clear updates to Discovery, Preclinical, and Leadership; write technical reports, support patent filings, and prepare data packages for milestones
Qualification
Required
PhD in Molecular/Cell Biology, Biochemistry, Cancer Biology, Pharmacology or related field (or MS/BS with commensurate depth of industry experience)
5+ years of hands-on lab experience with a range of relevant research techniques including cell-based assays and molecular biology. In vivo mouse experience is strongly preferred
Understanding of the drug development process from target identification to marketing authorization is strongly encouraged
Excellent communication, organizational, and problem-solving skills
Ability to collaborate well with team members
Preferred
Direct experience in CIN‑relevant biology (mitosis, microtubules/kinetochore function, replication stress, DNA‑damage response) or image‑based phenotyping
In vivo oncology familiarity (xenograft/PDX syngeneic models), PK/PD thinking, and translational biomarker awareness for discovery‑to‑development continuity
Company
Volastra Therapeutics
Volastra Therapeutics is a biotechnology company developing novel therapies for the treatment of metastatic cancers.
11-50 employees
H1B Sponsorship
Volastra Therapeutics has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (1)
2023 (1)
2022 (1)
Funding
Current Stage
Early StageTotal Funding
$149.1MKey Investors
Polaris Partners
2025-09-23Series A· $30.1M
2024-05-30Series Unknown· $15M
2023-03-07Series A· $60M
Leadership Team
David Southwell
Chief Executive Officer
Timothy Bowler
Chief Medical Officer
Recent News
2026-01-11
Crain's New York Business
2025-09-26
Company data provided by crunchbase