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10x Genomics · 1 day ago

Sr. Manager, Diagnostic Assay Development

Pleasanton, CA

Full-time

Onsite

Senior Level, Lead/Staff

$180K/yr - $243K/yr

10+ years exp

10x Genomics is committed to accelerating the understanding of biology and enabling scientists to advance their research. The Sr. Manager of Diagnostic Assay Development will lead the design, prototyping, and validation of laboratory developed tests, managing a small R&D lab team and collaborating with various stakeholders to ensure the successful clinical application of advanced assay technologies.

Biotechnology

H1B Sponsor Likely

Responsibilities

Design, prototype, troubleshoot, and optimize single-cell and spatial assays for clinical application

Develop and document robust assay workflows suitable for transfer into CLIA environments

Plan and oversee analytical validation studies, including accuracy, precision, sensitivity, specificity, reproducibility, and robustness testing

Lead method development for automation, throughput, and quality improvements

Direct laboratory execution of large-scale clinical research studies, including partnerships with leading academic centers processing thousands of tumor and blood samples

Work with external collaborators to generate and interpret data that demonstrate clinical validity and utility

Coordinate with bioinformatics and translational teams to align assay development with biomarker discovery and clinical readout requirements

Act as the primary technical resource for the CLIA operations team

Collaborate with 10x platform and product teams to translate emerging technologies into clinically deployable assays

Manage and mentor a small team of scientists and research associates in a hands-on laboratory environment

Represent the diagnostic assay development function to internal leadership and external partners, providing clear communication of technical plans, progress, and results

Contribute to scientific manuscripts and presentations at major conferences

Build and maintain processes that ensure scientific rigor, regulatory readiness, and operational scalability

Help establish the laboratory infrastructure, quality systems, and best practices needed for clinical assay development

Contribute to the diagnostic strategy and roadmap for 10xDx

Qualification

Clinical assay developmentMolecular profiling technologiesNGSSingle-cell assaysSpatial transcriptomicsRegulated diagnostics environmentAnalytical validationScientific rigorLeadershipCollaborationCommunicationDetail-oriented

Required

PhD in molecular biology, immunology, bioengineering, or related field

Minimum of 10 years' experience in clinical assay development, including 5 or more in a leadership role within a regulated diagnostics environment

Proven success developing and validating complex molecular assays (e.g., NGS, single-cell, spatial transcriptomics, multiplex imaging)

Demonstrated ability and enthusiasm to lead assay design, troubleshooting, and validation hands-on at the bench

Experience collaborating across research, development, and clinical teams

Familiarity with analytical validation requirements and CAP/CLIA standards

Technically strong, detail-oriented, and driven by scientific rigor

Driven, thoughtful, and ambitious, with a high sense of ownership and urgency

Comfortable working at multiple levels—from day-to-day lab management to strategic planning and partner engagement

Motivated by building something new and impactful in the diagnostic space

Benefits

10x’s equity grants

Comprehensive health and retirement benefit programs

Annual bonus program or sales incentive program

Company

10x Genomics

Glassdoor3.5

Cells are the basic unit of life.

Founded in 2012

Pleasanton, California, US

1001-5000 employees

http://10xgenomics.com

H1B Sponsorship

10x Genomics has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)

Distribution of Different Job Fields Receiving Sponsorship

Represents job field similar to this job

Trends of Total Sponsorships

2025 (41)

2024 (40)

2023 (35)

2022 (52)

2021 (34)

2020 (16)