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Crinetics Pharmaceuticals · 1 day ago

Principal Scientist, In Vitro Pharmacology

San Diego, CA

Full-time

Onsite

Senior Level, Lead/Staff

$158K/yr - $197K/yr

8+ years exp

Crinetics Pharmaceuticals is a pharmaceutical company based in San Diego, California, developing therapies for endocrine diseases. They are seeking a highly motivated Principal Scientist with experience in GPCR pharmacology to lead in vitro pharmacology efforts and support drug discovery programs.

BiotechnologyHealth CarePharmaceuticalTherapeutics

Responsibilities

Lead and manage a small team of junior scientists, promoting collaboration, efficiency, and innovative science

Design, develop, validate, and execute in vitro assays that support drug discovery programs

Conduct critical analysis and interpret data into meaningful understanding of small molecule ligand activity and mechanism of action

Demonstrate high level of initiative to oversee, troubleshoot, and accurately perform data analysis in an environment that values scientific integrity and quality

Conduct resource management to deliver critical in vitro pharmacology data to support multiple programs simultaneously

Lead and/or provide in vitro pharmacology leadership role on cross-functional program teams

Interpret and demonstrate effective written and oral communication of results to interdisciplinary teams

Participate in the strategic planning of departmental growth and organization

Lead external collaborations and outsourced studies

Identify and evaluate new research targets within therapeutic areas of interest

Author scientific publications and prepare technical reports to support regulatory submissions

Ensure compliance with company established practices and procedures, including laboratory notebooks, computer files, quality and regulatory guidelines, and safety standards

Other duties as assigned

Qualification

GPCR pharmacologyDrug discoveryVitro assaysBiochemical assaysData analysisExperimental designTeam managementWritten communicationVerbal communicationProblem-solving

Required

Ph.D. in Pharmacology, Biochemistry, Biology, or related discipline with a minimum of 8 years of relevant experience. Applicants with BS or MS degrees must demonstrate a minimum of 18 years of significant and relevant experience

At least 7 years of experience with drug discovery and small molecule pharmacology at therapeutically relevant GPCRs or related field

Demonstrated technical proficiency in biochemical, cellular, and/or radioligand binding assay systems and ability to ensure highest quality of in vitro assay data

Ability to independently determine in vitro pharmacologic methods and procedures to achieve Program goals

Outstanding experimental design, problem-solving, and data analysis skills and the ability to independently establish in vitro pharmacologic approaches to achieve program goals

Demonstrated practical experience and deep understanding of in vitro pharmacological theory, models, mechanisms, and experimental design, particularly with GPCRs

Must be independent and able to follow pre-established experimental designs, as well as develop new methods, protocols, and technologies based on existing literature

Strong work ethic and enthusiasm for a mix of laboratory work and management in a dynamic environment

Strong written and verbal communication skills and ability to work effectively in a multidisciplinary team environment

Experience with writing reports and technical regulatory documents

Must be detail-oriented, punctual, and reliable

Ability to work in a fast-paced environment and adapt to change