Inotiv · 1 day ago
Sr. Leader Discovery Toxicology
St Louis, MO
Full-time
Hybrid
Director/Executive
$150K/yr - $200K/yr
15+ years expInotiv is a growing contemporary drug discovery and development company, and they are seeking a Senior Director of Discovery Toxicology to provide scientific and strategic leadership within the Integrative Toxicology function. The role involves overseeing Investigative Toxicology efforts, enhancing translational relevance, and supporting drug development programs through collaboration and innovative toxicology strategies.
BiopharmaLife ScienceMedical DevicePharmaceutical
Responsibilities
Design and implement modern toxicology strategies to support all stages of discovery as well as new indications investigations during clients’ phased clinical studies and/or post-marketed therapeutics
Drive the integration of toxicology as practiced at Inotiv’s multiple sites into a single, coordinated network that operates with shared goals, stage-appropriate standards, and best practices
Lead mechanistic investigations using in vitro, in vivo, and ex vivo approaches
Contribute to the scientific advancement and programmatic inclusion of Novel Alternative Methods (NAM) in the Pharmacologic and Toxicologic assessment of therapeutics
Evaluate species relevance to improve translatability of nonclinical findings to human risk
Collaborate cross-functionally with pharmacology, DMPK, pathology, bioinformatics, and clinical teams to integrate data and guide compound development
Contribute to the discovery and application of translational safety biomarkers to support preclinical-to-clinical transitions
Anticipate and mitigate safety liabilities early in the discovery process, including off-target effects and distinguishing adaptive from adverse responses
Mentor and develop a high-performing team of toxicology investigators and laboratory scientists
Represent Discovery Toxicology in internal project teams, governance forums, and external regulatory interactions, as needed
Monitor scientific and regulatory advancements to continuously innovate and evolve toxicology strategies
Lead a multidisciplinary team including Study Directors, Investigators, and Technical Scientists
Complete assigned all assigned training
All other duties as assigned
Other special projects and duties as assigned
Qualification
Required
PhD in Toxicology, Pharmacology, or a related biomedical science, with 15+ years of experience in discovery or investigative toxicology within the pharmaceutical, biotech, or CRO industry
Proven expertise in designing and interpreting in vitro, in vivo, and ex vivo toxicology studies to investigate mechanisms of toxicity
Track record of successfully supporting drug discovery programs from hit identification through candidate nomination
Deep understanding of molecular and cellular toxicology, interspecies differences, drug metabolism, and mechanisms of human relevance
Strategic thinker with the ability to synthesize complex scientific data into actionable development plans
Strong leadership skills with experience managing and developing scientific teams
Excellent communication and cross-functional collaboration skills
Proficiency with Microsoft Office Suite (Word, Excel, PowerPoint, Outlook) is required
Preferred
Additional qualifications such as DVM or Board Certification in Pathology are strongly preferred
Experience in biomarker discovery and translational safety assessments is highly desirable
Benefits
Health and dental coverage
Short- and long-term disability
Paid time off
401K participation with company match
Paid parental leave
401K
Company
Inotiv
Inotiv provides biopharmaceutical analytical, reproductive toxicology, medical device testing, DMPK, consulting and pathological services.
1001-5000 employees
H1B Sponsorship
Inotiv has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (1)
2024 (1)
2023 (2)
2022 (1)
Funding
Current Stage
Public CompanyTotal Funding
$27.64MKey Investors
Indiana Economic Development Corporation
2024-12-18Post Ipo Equity· $27.6M
2022-06-20Grant· $0.04M
1997-11-28IPO
Leadership Team
Greg Beattie
Chief Operating Officer
Recent News
2025-12-13
2025-12-11
Company data provided by crunchbase