Genentech ยท 1 day ago
MES Engineer
Oceanside, CA
Full-time
Onsite
Senior Level
$80K/yr - $150K/yr
5+ years expGenentech is a leading biotechnology company, and they are seeking an MES Engineer to play a key role in their highly automated pharmaceutical drug substance facility. The role involves maintaining and optimizing the Manufacturing Execution System (MES), collaborating with cross-functional teams, and ensuring compliance with regulatory standards in a 24x7 Good Manufacturing Practice (GMP) environment.
BiotechnologyLife ScienceManufacturing
Responsibilities
Design, implement, and optimize SQL Server databases supporting MES
Develop complex SQL queries, stored procedures, functions, and triggers
Perform database tuning, indexing, and query optimization for performance and scalability
Manage backups, restores, disaster recovery plans, and high-availability configurations
Build data extracts and reporting views for manufacturing and quality stakeholders
Configure, deploy, and maintain MES software (Emerson Syncade or Pharamsuite)
Lead MES upgrades, patch management, and change controls
Troubleshoot MES application issues across the stack (UI, middleware, backend)
Manage Active Directory integration, user/group access control, and system security
Monitor server performance, capacity, and uptime with proactive alerts and logs
Support virtualization (VMware) and system redundancy for critical GMP applications
Ensure systems meet GxP and FDA 21 CFR Part 11 requirements
Author/execute technical validation documents (URS, FRS, DS, IQ/OQ/PQ)
Support internal and external audits by providing technical and compliance evidence
Integrate MES with ERP, LIMS, DCS, and automation systems
Partner with Manufacturing, QA, Validation, and IT teams to deliver compliant, efficient solutions
Mentor junior engineers on SQL/database best practices, MES configuration, and system administration
Qualification
Required
5 - 6 years of MES experience in biotech, pharma, or other GMP-regulated manufacturing
Advanced SQL Server skills (query optimization, schema design, indexing, performance tuning)
Strong Windows Server and Active Directory administration
Hands-on experience with MES platforms (Emerson Syncade or Pharmasuite)
Proven ability to troubleshoot system issues across multiple layers (application, DB, OS, infrastructure)
Strong understanding of GxP, GMP (CSV methodologies optional)
Preferred
Scripting/automation (PowerShell, Python, or Bash)
Experience with virtualization platforms (VMware, Hyper-V)
Reporting/analytics tools (Crystal Reports)
Knowledge of integrating MES with automation and shop floor systems (OPC)
Benefits
A discretionary annual bonus may be available based on individual and Company performance.
This position also qualifies for the benefits detailed at the link provided below.
Company
Genentech
Genentech is a biotechnology research company that specializes in genetic testing and personalized medicines.
10001+ employees
H1B Sponsorship
Genentech has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (167)
2024 (148)
2023 (150)
2022 (178)
2021 (121)
2020 (158)
Funding
Current Stage
Public CompanyTotal Funding
unknown2009-03-26Acquired
1999-07-20IPO
1976-01-01Series Unknown
Leadership Team
Ashley Magargee
Chief Executive Officer
Michael Laird
Vice President
Recent News
2026-01-07
MarketScreener
2026-01-06
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