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Dovetail Therapeutics · 1 month ago

Senior/Principal Scientist, Protein Engineering

Seattle, WA

Full-time

Onsite

Senior Level

5+ years exp

Dovetail Therapeutics is a Seattle biopharmaceutical company focused on developing novel biotherapeutics. They are seeking a Senior/Principal Scientist in Protein Engineering to lead discovery and optimization efforts for antibody candidates and collaborate with cross-functional teams to advance biotherapeutics.

Biotechnology

Responsibilities

Lead and contribute to discovery and optimization efforts for antibody candidates

Work with internal cross-functional teams and CROs to design and advance novel biotherapeutics

Develop and implement innovative strategies and methodologies to accelerate antibody discovery and engineering workflows

Analyze and effectively communicate ideas and findings to internal stakeholders

Qualification

Antibody engineeringProtein scienceMolecular biologyAI/ML-driven modelingHigh-throughput data integrationCommunication skillsOrganizational skills

Required

Ph.D. degree in structural biology, molecular biology, biochemistry or a related field

5+ years of experience in antibody discovery and protein engineering in an academic or industry setting; 2+ years of industry experience strongly preferred

Expertise in antibody and protein science, molecular biology, and biotherapeutic discovery

Hands-on experience in therapeutic protein and antibody engineering, particularly with optimization of molecular properties, affinity maturation, and/or antibody humanization

Proven ability in applying state-of-the-art antibody engineering approaches, sequence analysis, and computational tools to shape design strategy and optimize workflows

Ability to synthesize functional and biophysical data and integrate high-throughput datasets to guide selection and engineering strategies

Stay current on emerging trends in protein design and introduce innovative techniques to expand team capabilities

Excellent organizational and communication skills with attention to detail

Ability to work in a fast-paced, interdisciplinary environment