Alnylam Pharmaceuticals · 22 hours ago
Associate Director, Statistical Genetics
Cambridge, MA
Full-time
Onsite
Lead/Staff, Director/Executive
$167K/yr - $226K/yr
8+ years expAlnylam Pharmaceuticals is a leader in RNAi therapeutics, seeking an Associate Director to lead their large-scale statistical genetics capability. The role involves performing genetic association studies, managing a team, and contributing to the analysis of genetic data from multiple biobanks to discover new therapeutic targets.
BiotechnologyHealth CareMedicalPharmaceuticalTherapeutics
Hiring Manager
Jeannine Ripley
Responsibilities
Perform common and rare genetic association studies, including large “all by all” analyses, using biobank-scale data (e.g., UK Biobank, All of Us, Our Future Health, Alliance for Genomic Discovery) with the aim of finding new targets for RNAi therapeutics
Conduct cross-biobank meta-analyses, including leveraging publicly available summary statistics
Organize these results in a manner that facilitates their use by the broader team
Perform post-GWAS analyses aimed at identifying causal genes and potential therapeutic targets (e.g., fine-mapping, colocalization, Mendelian randomization)
Identify, evaluate and implement the latest statistical genetics innovations and analytical methods to help us make discoveries
Manage, coach and develop a small team focused on biobank-scale analyses, ensuring scientific rigor and timely delivery of results
Prepare, review, and deliver high quality scientific manuscripts and presentations for internal and external use
Qualification
Required
PhD in Statistical Genetics or a related field with 8+ years of relevant post-graduate experience
Proven track record of managing people and driving teams to produce results
Deep understanding of statistical genetics including GWAS and RVAS methods (e.g., single variant testing, burden, SKAT) and extensive experience implementing relevant statistical packages (e.g., REGENIE, PLINK)
Extensive experience processing and analyzing individual-level biobank-scale genetic, phenotypic, and multi-omic data (e.g., proteomics), and a track record of making novel discoveries using these data
Proven track record of performing multi-biobank analyses, including performing meta-analyses (e.g., using METAL, RAREMETAL, REMETA), and understanding of meta-analytic approaches for handling sample overlap
Demonstrated experience in applying variant-to-gene post-GWAS methods (statistical fine-mapping, colocalization, Mendelian randomization)
Experience with statistical genetics approaches and scalable tools for multivariate phenotype analysis, time-to-event and longitudinal analysis, and leveraging genetic ancestrally diverse datasets to improve signal detection and resolution
Hands-on experience conducting processing and QC of biobank-scale individual-level genetic data (WGS, WES, imputed)
Expertise in phenotype generation as well as cross-biobank phenotype curation and harmonization
Experience working on a Linux command line and advanced hands-on knowledge of Python and R
Practical experience implementing genomics workflows on cloud-based platforms such as DNAnexus, All of Us Researcher Workbench, Terra
Excellent communication skills, an ability to work collaboratively and cross-functionally, and a track record of publishing in high impact scientific journals
Benefits
Comprehensive benefits including medical, dental, and vision coverage
Life and disability insurance
A lifestyle reimbursement program
Flexible spending and health savings accounts
A 401(k) with a generous company match
Paid time off
Wellness days
Holidays
Two company-wide recharge breaks
Generous family resources and leave
Company
Alnylam Pharmaceuticals
Alnylam Pharmaceuticals is a biopharmaceutical company focused on the discovery, development and commercialization.
1001-5000 employees
H1B Sponsorship
Alnylam Pharmaceuticals has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2022 (18)
2021 (19)
2020 (7)
Funding
Current Stage
Public CompanyTotal Funding
$4.55BKey Investors
Blackstone Life SciencesBlackstone CreditRegeneron
2025-09-09Post Ipo Debt· $661.25M
2022-09-12Post Ipo Debt· $900M
2022-03-04IPO
Leadership Team
Yvonne Greenstreet
Chief Executive Officer
Jeff Poulton
Chief Financial Officer
Recent News
2025-12-22
2025-12-20
Company data provided by crunchbase