St. Jude Children's Research Hospital · 1 month ago
Scientist or Senior Scientist Opportunity in the St Jude cryoEM/ET center
Memphis, TN
Full-time
Onsite
Mid, Senior Level
$104K/yr - $186K/yr
3+ years expSt. Jude Children's Research Hospital is seeking a highly motivated Scientist or Senior Scientist to join their cryoEM/ET center. The role involves providing support for cryo-ET workflows, collaborating with researchers, and contributing to the strategic growth of cryo-ET capabilities.
BiotechnologyCharityHealth CareHealth DiagnosticsHospitalMedicalNon Profit
Responsibilities
Provide hands-on support for cryo-ET sample preparation, including plunge freezing, high-pressure freezing, cryo-CLEM workflows, cryo-FIB lamella preparation, and TEM screening
Operate, maintain, and monitor high-end cryo-EM instrumentation (Titan Krios, Glacios, Arctica and Aquilos 2) to ensure optimal performance and maximize user access
Train new and experienced users in cryo-ET techniques, microscope operation, and best-practice standards aligned with cryoEM/ET center’s guidelines
Work closely with researchers to design and execute tomography data-collection strategies that meet research goals
Perform initial quality assessment of tilt-series data and assist users with reconstruction and early-stage data processing
Participate in development and optimization of emerging cryo-ET workflows, protocols, and automation strategies
Maintain accurate documentation related to user training, sample preparation sessions, instrument usage, and standard operating procedures
Contribute to a safe, inclusive, and service-focused environment that reflects St. Jude’s commitment to excellence and collaboration
Qualification
Required
Bachelor's degree in relevant scientific area is required
Eight (8) years of relevant work experience is required with a Bachelor's degree
Six (6) years of relevant work experience is required with a Master's degree
Three (3) years of relevant work experience is required with a PhD
Ten (10) years relevant work experience is required with a Bachelor's degree for Senior Scientist level
Eight (8) years of relevant work experience is required with a Master's degree for Senior Scientist level
Five (5) years of relevant work experience is required with a PhD for Senior Scientist level
Preferred
PhD or equivalent degree in Structural Biology, Biophysics, Biochemistry or a related field
Demonstrated experience with cryo-EM workflows, ideally including cryo-ET sample preparation, lamella milling, and tomography data acquisition
Strong understanding of microscope alignment, image acquisition parameters, and cryo-EM instrumentation
Hands-on experience with tilt-series acquisition, tomogram reconstruction, and subtomogram averaging pipelines (e.g., IMOD, Dynamo, RELION, M/Warp, EMAN2)
Ability to troubleshoot complex workflows and assist users with technical challenges
Excellent communication skills for working in a diverse, multi-disciplinary user environment
Interest in technology development, workflow automation, or method optimization
Benefits
Medical & Prescription Drug Plans
Dental Plan
Vision Plan
Financial Security
Retirement Plan
Living Well - Employee Wellness Program
Time Off Programs
Educational Benefits
Family Friendly Benefits
Benefits Unique to St. Jude
Company
St. Jude Children's Research Hospital
St.
5001-10000 employees
H1B Sponsorship
St. Jude Children's Research Hospital has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (370)
2024 (316)
2023 (309)
2022 (255)
2021 (251)
2020 (201)
Funding
Current Stage
Late StageTotal Funding
$62.4MKey Investors
Kia MotorsKBR Charity Golf TournamentHyundai Hope On Wheels
2025-05-12Grant· $1.5M
2024-10-28Grant
2024-08-28Grant· $0.4M
Leadership Team
Judy A. Habib
Chair, Board of Directors
Recent News
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