Senior Principal Statistical Programmer jobs in United States
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Syneos Health · 2 months ago

Senior Principal Statistical Programmer

positionUnited States
timeFull-time
remoteRemote
senioritySenior Level, Lead/Staff
date10+ years exp

Syneos Health® is a leading fully integrated biopharmaceutical solutions organization built to accelerate customer success. The Senior Principal Statistical Programmer will be responsible for leading studies independently, managing communication with clients, and driving end-to-end study delivery with minimal oversight.

BiotechnologyHealth CarePharmaceuticalTherapeutics
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H1B Sponsor Likelynote

Responsibilities

Strong ADaM expertise
ADaM specification creation
ADaM programming and review
Handling complex ADaM and TFL programming tasks
In-depth CDISC knowledge
Strong understanding and application of CDISC standards
Proven study-leading experience
Must have led at least 4–5 studies independently (not just co-led/supporting lead)
Experience leading multiple trials simultaneously (large/global studies preferred)
Ability to drive end-to-end study delivery with confidence and minimal oversight
Exposure to oversight and coordination across portfolios (especially for ISS)
Prior ISS (Integrated Summary of Safety/Efficacy) experience — preferred but not mandatory
Exposure to handling multiple study designs
Understanding of integration workflows

Qualification

ADaM expertiseCDISC knowledgeStudy managementClient-facing communicationTeam collaboration

Required

10+ years overall experience
Strong technical expertise in ADaM and CDISC
Strong ADaM expertise
ADaM specification creation
ADaM programming and review
Handling complex ADaM and TFL programming tasks
In-depth CDISC knowledge
Strong understanding and application of CDISC standards
Experience across multiple phases: Phase I, II, and III
Client-facing communication skills
Ability to interact directly with technical client leads
Manage communication without US-based counterparts
Proven study-leading experience
Must have led at least 4–5 studies independently
Experience leading multiple trials simultaneously
Ability to drive end-to-end study delivery with confidence and minimal oversight
Exposure to oversight and coordination across portfolios

Preferred

Prior ISS (Integrated Summary of Safety/Efficacy) experience
Exposure to handling multiple study designs
Understanding of integration workflows

Benefits

Career development and progression
Supportive and engaged line management
Technical and therapeutic area training
Peer recognition
Total rewards program

Company

Syneos Health

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Syneos Health, the only fully integrated end-to-end clinical and commercial solution organization.
dateFounded in 1985
location
Morrisville, North Carolina, USA
people-size10001+ employees
web-link
https://www.syneoshealth.com/

H1B Sponsorship

Syneos Health has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (35)
2024 (26)
2023 (49)
2022 (63)
2021 (84)
2020 (63)

Funding

Current Stage
Public Company
Total Funding
$524.65M
2023-09-28Private Equity
2023-05-10Acquired
2021-03-01Post Ipo Secondary· $524.65M

Leadership Team

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Michael Bonello
Executive Vice President and Chief Financial Officer
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Michael Brooks
Chief Operating Officer
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Recent News

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Syneos Health Appoints Simon Bartle as Chief Human Resources Officer
2026-01-09
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2026-01-05
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Company data provided by crunchbase