Disc Medicine · 1 month ago
Senior Principal Clinical Scientist
Massachusetts - Hybrid
Full-time
Hybrid
Senior Level, Lead/Staff
$209K/yr - $283K/yr
12+ years expDisc Medicine is a clinical-stage biopharmaceutical company committed to discovering, developing, and commercializing novel treatments for patients who suffer from serious hematologic diseases. This role involves supporting the DISC-3405 program focused on hepcidin induction and iron restriction, and working with a cross-functional team to drive the clinical program from early to late-stage studies.
BiotechnologyHealth CareMedicalPharmaceuticalTherapeutics
Responsibilities
Work directly with the Medical Director and the clinical study team in the execution of early-stage Phase 1 & 2, as well as pivotal, clinical trials
Collaborate cross-functionally with Medical Directors, Pharmacology, Innovation, Pharmacovigilance, external experts, and investigators to accumulate scientific, medical, and safety knowledge necessary to support clinical development plans, study designs, investigator brochures, and protocols
Work closely with contract research organizations and the internal Disc team to strategize and meet timelines
Monitor and review safety and efficacy data in ongoing studies with the Medical Monitor
Represent the clinical study team at the clinical sub team and program team meetings and collaborate with the clinical team to lead data capture and analysis
Develop and maintain relationships with key opinion leaders and principal investigators
Participate in Investigator meeting planning and execution and/or on-site initiation meetings
Lead internal and external team members, vendors, and consultants to develop, review and evaluate efficacy and safety data for external presentation and regulatory submissions
Review and content of clinical and regulatory documents, including protocols, INDs, CTAs, investigator brochures, CRFs, annual IND reports, CSRs, and clinical expert reports
Organize and present at clinical advisory boards, investigator meetings, DMC and SRC meetings, and medical/scientific meetings
Support strategy and business development processes for in- or out-licensing, partnering and acquisition activities
Maintain awareness of internal and external developments (scientific, clinical, competitive, and regulatory) including attendance at major scientific conferences, participation in competitive intelligence activities, and periodic literature review
Critically evaluate available information about diseases of interest to the therapeutic area and the competitive landscape while synthesizing information to support its dissemination and incorporation into clinical development, asset plans, and therapeutic area strategy
Travel periodically both nationally and internationally
Qualification
Required
PhD, PharmD, or MD with research experience
12+ years of related experience in translational or clinical research related to drug development. Inhouse biotech/ pharma experience preferred
Knowledge in the principles of clinical research methodology, statistics, data analysis and interpretation and ability to think strategically and analyze data while executing study responsibilities
Willingness to take on new responsibilities and expand professional skills and experience and able to execute in a high-paced environment
Experience with developing clinical regulatory strategy
Ability to identify and build relationships with thought leaders and leading clinical centers
Strong academic record demonstrating research productivity is a plus
Track record of effective cross-collaboration within an organization, among teams, and external groups/organizations
Ability to clearly and effectively communicate to internal and external stakeholders orally and in writing
Experience in interacting with varying levels of internal/external management, academicians, clinicians, scientists, etc
Strong business acumen; including in-depth knowledge of the multidisciplinary functions involved in a company's drug development process, e.g., clinical operations, biostatistics, regulatory, commercial operations, etc. and can proactively integrate multiple perspectives into the clinical development process for best end-results
Benefits
Comprehensive benefits
Competitive compensation packages
Company
Disc Medicine
Disc Medicine is a biopharmaceutical company that develops therapies for hematologic diseases and rare blood disorders.
51-200 employees
H1B Sponsorship
Disc Medicine has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (1)
2024 (1)
2022 (1)
Funding
Current Stage
Public CompanyTotal Funding
$1.29BKey Investors
Hercules CapitalFrazier Life SciencesBain Capital Life Sciences
2025-10-21Post Ipo Secondary· $25M
2025-10-21Post Ipo Equity· $225M
2025-01-22Post Ipo Equity· $225.5M
Leadership Team
Jean Franchi
Chief Financial Officer
Jonathan Yu
Chief Operating Officer
Recent News
2026-01-07
Company data provided by crunchbase