Children's National Hospital · 4 days ago
Sr Bioinformatics Scientist
Washington, DC
Full-time
Onsite
Senior Level, Lead/Staff, Director/Executive
$118K/yr - $118K/yr
8+ years expChildren's National Hospital is seeking a Senior Bioinformatics Scientist to serve as Assistant Director of the BTI Bioinformatics Core. This leadership role involves providing scientific and technical leadership while mentoring Bioinformatics Scientists and conducting hands-on computational biology analyses for the Rare Brain Tumor Program.
AssociationChild CareHealth CareNon Profit
Responsibilities
Provide scientific and technical leadership as the Core’s primary “go-to” expert for methodological guidance, code standards, QC frameworks, and pipeline development
Mentor Bioinformatics Scientists and support Core infrastructure
Split time between scientific oversight, project guidance, and code review and hands-on computational biology analyses for the Rare Brain Tumor Program
Design and execute robust statistical analyses across diverse genomic and proteomic data types
Collaborate with investigators to determine the most effective computational approaches to complex problems with biological context
Lead the development and implementation of novel and optimized workflows for large-scale -omic datasets
Resolve advanced, multi-layered bioinformatics and workflow issues independently
Lead preparation of figures, written analysis, and supplemental methods for manuscripts, grants, and collaborators
Partner with investigators, clinicians, project leads, and other bioinformatics staff to define project goals, analysis strategies, coordinate data workflows, and support scientific goals
Qualification
Required
Doctor of Philosophy (Ph.D.) Biological or computational discipline
8–15 years in applied bioinformatics, genomics, and computational work (can be inclusive of relevant computational Ph.D. dissertation years)
Advanced proficiency in UNIX/Linux environments
Expert-level programming and data analysis skills in R, Python, or equivalent
Deep experience with NGS, microarray, multi-omics, and other high-throughput platforms and their application to specific biological questions
Expertise with a broad range of bioinformatics tools, pipelines, and genomic databases, such as GATK, UCSC Genome Browser, Bioconductor, ENCODE, NCBI, Kids First, gnomAD, ClinVar, OMIM, HGMD, and COSMIC
Demonstrated expertise in GitHub, containerization (Docker, Podman, and/or Singularity), and workflow automation
Strong grasp of workflow management tools (e.g., Snakemake, Nextflow, WDL, CWL)
Expertise using high-performance computing (HPC) environments and/or cloud platforms (e.g., AWS, Google Cloud) for large-scale analyses
Ability to develop user-facing bioinformatics applications using tools such as RShiny or Python Streamlit
Demonstrated ability to design and execute robust statistical analyses across diverse genomic and proteomic data types
Deep expertise interpreting and visualizing results in biological or clinical contexts
Deep domain expertise in at least one disease area or biological system through publications, pipelines, tools, and/or open-source contributions
Experience writing scientific manuscripts, figure and methods development, and manuscript authorship
Ability to lead complex interdisciplinary projects and guide teams from analysis to publication
Strong mentorship skills and demonstrated ability to train junior scientists and analysts
Excellent organizational, communication, and presentation skills
Proven ability to interact effectively with investigators, clinicians, laboratory staff, peers, and institutional leadership
Commitment to open and team science practices, including transparency, reproducibility, shared documentation, and collaborative problem-solving
Familiarity with project management tools and methodologies such as Scrum, Agile, Jira, GitHub Projects, Trello, or Asana to coordinate timelines, tasks, and deliverables across teams
Uphold the highest ethical standards and integrity in all scientific activities
Ensure data privacy and patient confidentiality standards
Maintain reproducibility and transparency in code, workflows, and documentation
Properly cite software tools, data sources, and collaborators
Comply with institutional policies and federal regulations governing research and data use
Lead the development and implementation of novel and optimized workflows for large-scale -omic datasets
Design rigorous statistical frameworks that align with study goals and clinical hypotheses
Collaborate with investigators to determine the most effective computational approaches to complex problems with biological context
Contribute significantly to high-impact publications and grant proposals
Resolve advanced, multi-layered bioinformatics and workflow issues independently
Design scalable, sustainable solutions to recurring analysis or infrastructure challenges
Serve as technical advisor to junior bioinformatics staff, providing design, optimization, and troubleshooting support
Lead preparation of figures, written analysis, and supplemental methods for manuscripts, grants, and collaborators
Clearly present findings and strategy in lab/collaborator meetings, present journal clubs, and attend scientific conferences
Provide strategic guidance to principal investigators on computational planning in proposals
Partner with investigators, clinicians, project leads, and other bioinformatics staff to define project goals, analysis strategies, coordinate data workflows, and support scientific goals
Lead multidisciplinary bioinformatics collaborations from project inception through delivery
Mentor junior scientists and analysts in bioinformatics methods, code quality, and scientific interpretation
Foster a culture of scientific rigor, reproducibility, and learning
Contribute reusable, well-documented code to team repositories
Coordinate timelines and deliverables using project management tools (e.g., Jira, GitHub Projects, Asana) and collaborative workflows
Contribute to and lead the development of open-source software, reproducible workflows, and institutional tooling
Stay abreast of innovations in bioinformatics tools, databases, and standards
Organize and develop training workshops, tutorials, and best-practice guides to advance team-wide and institutional bioinformatics capacity
Deepen domain-specific expertise (e.g., pediatric cancer, neurodevelopment, rare disease) through literature synthesis, collaborations with subject matter experts, and community engagement
Represent the organization in consortia, workshops, and national/international scientific forums
Guide institutional practices in reproducibility, open science compliance, and infrastructure sustainability
Use domain knowledge to improve study design and analytical approaches to biological or clinical questions
Set and clearly communicate team goals and priorities in alignment with departmental goals and budgets
Develop the budget and assign resources to meet the team goals
Provide the resources and guidance required for employees to perform effectively
Develop procedures to ensure high safety and quality, and course-correct as needed
Identify customers' needs and ensure service excellence in meeting those needs
Be the link between the department and the team in defining the strategies to meet team goals
Provide prompt and clear feedback to staff and support their performance
Ensure team adherence to organizational regulations
Manage the working environment to promote productivity and motivation
Represent the team in clearing obstacles to high performance
Hire staff and develop their capabilities
Monitor and promote strong employee engagement
Encourage and share new ways of making the right work easier to do
Recognize and share incremental improvements in operations
Promote the success of organizational and department initiatives by clearly aligning programs to the mission
Company
Children's National Hospital
Children’s National Hospital, based in Washington, D.C., was established in 1870 to help every child grow up stronger.
Founded in 1870Washington, District of Columbia, USA
5001-10000 employees
H1B Sponsorship
Children's National Hospital has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (82)
2024 (55)
2023 (92)
2022 (59)
2021 (41)
2020 (51)
Funding
Current Stage
Late StageTotal Funding
$19.4MKey Investors
Gilbert Family FoundationAdvanced Research Projects Agency for HealthUnited Health Foundation
2025-10-09Grant· $8M
2024-10-23Grant· $8M
2021-11-09Grant· $3.4M
Leadership Team
Kurt Newman
President and CEO
Michelle Riley-Brown, MHA, FACHE
President and CEO
Recent News
BioWorld Financial Watch
2025-06-07
Company data provided by crunchbase