Senior Manager, Clinical Data Management jobs in United States
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Paradigm Health · 1 month ago

Senior Manager, Clinical Data Management

positionUnited States
timeFull-time
remoteRemote
senioritySenior Level, Lead/Staff
money$180K/yr - $210K/yr
date8+ years exp

Paradigm is rebuilding the clinical research ecosystem by enabling equitable access to trials for all patients. The Senior Manager of Clinical Data Management is responsible for overseeing the execution, quality, and operational excellence of data management activities across various studies, ensuring high-quality outcomes and driving cross-functional collaboration.

Health CareHealth DiagnosticsHospitalLife Science
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H1B Sponsor Likelynote

Responsibilities

Lead, mentor, and develop a high-performing team of Clinical Data Managers and CDM operations staff
Oversee workload allocation, staffing plans, competency development, and performance management
Foster a culture of excellence, continuous improvement, and accountability within the CDM function
Provide senior oversight of end-to-end CDM activities across multiple studies, including database development, CRF design, edit check specification, cleaning and reconciliation workflows, and database lock
Ensure predictable delivery of data management milestones through proactive oversight of timelines, metrics, and quality indicators
Anticipate operational risks and lead resolution efforts in collaboration with cross-functional partners
Collaborate closely with Clinical Operations, Biostatistics, Safety, Regulatory, Quality, Product, and Engineering to ensure integrated and efficient data delivery
Serve as a senior CDM representative in cross-functional study meetings, troubleshooting sessions, and strategic planning discussions
Align CDM workflows with broader study goals and portfolio-level priorities
Lead the development, refinement, and adoption of CDM SOPs, templates, libraries, and operational playbooks
Drive initiatives to streamline workflows, strengthen data quality controls, and enhance scalability across the CDM organization
Support digital transformation initiatives, including automation, modern EDC capabilities, and advanced data review tools
Serve as a senior CDM point of contact for sponsors, ensuring transparent communication, timely delivery, and trusted partnership
Provide proactive updates, risk assessments, and strategic recommendations to internal and sponsor stakeholders
Contribute to proposal development, data strategy discussions, and operational feasibility assessments for new and ongoing programs

Qualification

Clinical Data ManagementEDC systemsCDISC standardsData cleaning processesRegulatory requirementsLeadership experienceAnalytical skillsOperational excellenceContinuous improvementCommunication

Required

8–12 years of clinical data management experience, with substantial experience leading complex studies or multi-study portfolios
Proven leadership experience managing data teams and driving high-quality delivery in fast-paced environments
Deep expertise in EDC systems, CDISC standards, data cleaning and reconciliation processes, and regulatory requirements (ICH-GCP, 21 CFR Part 11, GDPR)
Strong communication skills with the ability to influence, collaborate, and lead across diverse technical and operational teams
Highly organized, analytical, and committed to data integrity, operational excellence, and continuous improvement
Able to operate strategically while remaining hands-on with complex problem-solving when needed

Benefits

Competitive health, dental, and vision insurance
Mental health support for you and your family through Spring Health
Equity package
Unlimited paid time off (PTO)
16 weeks of paid parental leave
Flexible work options – remote and hybrid arrangements
Company-paid life insurance
Company-paid short-term and long-term disability coverage
One Medical membership
401(k) plan with company match

Company

Paradigm Health

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Paradigm Health is rebuilding the clinical research ecosystem by creating a platform that enables equitable access to trials for all patients, while enhancing trial efficiency and reducing the barriers to participation for healthcare providers.
dateFounded in 2022
location
New York, New York, USA
people-size51-200 employees
web-link
https://www.paradigmhealth.ai/

H1B Sponsorship

Paradigm Health has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (1)
2024 (4)
2023 (1)
2022 (1)
2021 (4)
2020 (1)

Funding

Current Stage
Growth Stage
Total Funding
$281M
Key Investors
ARCH Venture Partners
2025-12-04Series B· $78M
2023-01-25Series A· $203M

Leadership Team

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Paul Kluetz
Chief Medical Officer
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