Roche · 1 month ago
Principal Software Engineer - Instrument Integration, Engineering - Lab Automation
South San Francisco
Full-time
Onsite
Senior Level, Lead/Staff
$163K/yr - $302K/yr
7+ years expRoche is dedicated to advancing science and healthcare access for future generations. The Principal Software Engineer will lead the architecture and implementation of high-impact software systems within the instrument integration domain, enabling scientists to access reliable data and accelerate drug discovery.
BiotechnologyHealth CareHealth DiagnosticsOncologyPharmaceuticalPrecision Medicine
Responsibilities
Define and lead the architecture and design of complex, cross-functional features within the instrument data ecosystem
Drive technical roadmaps for key software components of instrument data capture, processing, and distribution, aligning closely with the Computational Sciences Center of Excellence (CoE) goals
Set and enforce high technical standards for code quality, testing, deployment, and performance, serving as a mentor to engineers across the capability
Lead the investigation and resolution of critical, large-scale distributed system issues
Serve as a senior technical expert when collaborating with Genentech (gRED) and Pharma (pRED) scientists, the Data and Digital Catalyst (DDC) organization, and other engineering teams
Be accountable for delivering scalable and reliable instrument data integration projects
Qualification
Required
B.S. in Computer Science, Engineering, or a related field plus 7+ years of progressive experience in Biotech/Pharma, focused on architecting and deploying scalable software systems for scientific research
Demonstrated record of outstanding performance through technical leadership and deep, hands-on technical contributions
Expert technical knowledge of principles related to distributed systems, data engineering, software architecture, cloud-native architectures, and system design
Must possess the ability to define high-level technical architecture and execute complex technical work
Expert-level proficiency in Python and deep working knowledge of either Java or C#
Deep knowledge of lab workflows is essential
Extensive direct experience interfacing with a variety of scientific laboratory instruments (e.g., liquid handlers, plate readers, microscopes, mass spectrometers)
Expert level technical background in cloud-native architectures (ideally AWS)
Benefits
A discretionary annual bonus may be available based on individual and Company performance.
This position also qualifies for the benefits detailed at the link provided below.
Company
Roche
Roche is a pharmaceutical and diagnostics company that offers medicines and diagnostic tests for various medical conditions and diseases.
10001+ employees
H1B Sponsorship
Roche has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (12)
2024 (9)
2023 (6)
2022 (2)
2021 (2)
Funding
Current Stage
Public CompanyTotal Funding
$7.79BKey Investors
SoftBankSCALE AINovartis
2021-08-04Post Ipo Equity· $5B
2020-12-07IPO
2020-05-06Post Ipo Equity· $0.5M
Leadership Team
Alan Hippe
Member of the Executive Board - Group CFO
Christine Bakan
Global Head and VP of Software and Bioinformatics, Next Generation Sequencing
Recent News
2026-01-09
2026-01-07
Company data provided by crunchbase