Vertex Pharmaceuticals · 2 weeks ago
DMPK Senior Research Fellow - Biotherapeutics
Boston, MA
Full-time
Hybrid
Senior Level, Lead/Staff
$233K/yr - $349K/yr
15+ years expVertex Pharmaceuticals is a global biotechnology company that invests in scientific innovation. They are seeking a Senior Research Fellow to lead the DMPK strategy for their Biotherapeutics portfolio, guiding the development from early research through clinical phases and ensuring integration of key insights into decision-making.
BiotechnologyHealth CareMedicalPharmaceutical
Responsibilities
Serve as the DMPK Lead and/or supervise other DMPK leads for biotherapeutics programs, develop and execute DMPK scientific strategies from discovery through clinical development
Build and maintain strong collaborative partnerships with Biology, Preclinical Safety, Clinical Pharmacology, CMC and other R & D disciplines to align DMPK strategy with overall program goals and advance Vertex programs through discovery and development
Represent DMPK function on drug discovery and development teams and with Vertex R & D governance bodies, driving data-informed decisions related to PK, immunogenicity, disposition, metabolism, and biotransformation of biotherapeutics
Provide scientific and managerial leadership to the team in prioritizing and executing on key deliverables and project needs
Oversee design, execution, and interpretation of PK, ADME, and bioanalytical/immunogenicity assays for biotherapeutics and guide translational PKPD approaches to support dose selection and clinical projections
Provide clear communication on DMPK findings, implications, and recommendations to team members and senior leadership
Ensure scientific excellence and regulatory compliance in all necessary DMPK regulatory documents and reports to support drug development including investigator brochures, INDs (or equivalent), and marketing applications
Help shape long-term DMPK strategy, capabilities, and best practices for biotherapeutics across the organization
Participate in review of business development opportunities
Qualification
Required
PhD in Pharmacokinetics, Pharmaceutical Sciences, Biochemistry, Biology, or related field, with 15+ years of industry experience
Successful track record and experience in a DMPK lead role on multiple R&D teams across more than one therapeutic area
Extensive experience working with one or more biotherapeutic modalities (e.g., protein, antibody and nucleic acid therapeutics, cell and gene therapies) is a must
Deep scientific and strategic expertise in various components of DMPK science such as PK, ADME, bioanalysis, immunogenicity, biotransformation, and translational PKPD modeling approaches for biologics
Excellent communication skills and ability to develop and grow strong cross-site/function collaborations
Experience preparing regulatory submissions and interacting with health authorities
Strong management and leadership skills, with emphasis on developing and mentoring junior DMPK project leads
Benefits
Annual bonus
Annual equity awards
Overtime pay
Medical, dental and vision benefits
Generous paid time off (including a week-long company shutdown in the Summer and the Winter)
Educational assistance programs including student loan repayment
Generous commuting subsidy
Matching charitable donations
401(k)
Company
Vertex Pharmaceuticals
Vertex Pharmaceuticals is focused on the discovery and development of small molecule drugs for the treatment of serious diseases.
5001-10000 employees
H1B Sponsorship
Vertex Pharmaceuticals has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (188)
2024 (150)
2023 (111)
2022 (164)
2021 (112)
2020 (80)
Funding
Current Stage
Public CompanyTotal Funding
$657.31MKey Investors
Janssen Belgium
2024-07-10Post Ipo Secondary· $1.11M
2022-05-17Post Ipo Equity· $50M
2009-12-03Post Ipo Equity· $443M
Leadership Team
Reshma Kewalramani
CEO and President
Nina Devlin
Senior Vice President, Chief Communications Officer
Recent News
2026-01-16
Pharmaceutical Technology
2026-01-15
2026-01-13
Company data provided by crunchbase