Guardant Health · 2 weeks ago
Senior Staff Bioinformatics Scientist
Palo Alto, CA
Full-time
Hybrid
Senior Level, Lead/Staff
$163K/yr - $224K/yrGuardant Health is a leading precision oncology company focused on guarding wellness and giving every person more time free from cancer. The role involves designing and deploying advanced predictive models for oncology applications using sequencing data, collaborating with scientific leaders, and turning models into impactful patient products.
BiotechnologyHealth CareHealth DiagnosticsOncologyTherapeutics
Responsibilities
Modeling & research
Build production-grade predictive models for oncology applications (e.g. therapy response, MRD, tumor characterization)
Develop advanced models (including deep learning-based architectures) for high dimensional and multimodal data leveraging extensive internal datasets
Advance self-supervised/foundation representations for genomic, DNA methylation, fragmentomics, and tissue imaging data
Design and execute validation plans; define performance targets and communicate results across functions to drive deployment of advanced models into production
Collaborate with external scientific leaders, medical affairs, laboratory directors, external collaborators to drive publications and conference presentations
Shape feature stores and reproducible pipelines from raw assay outputs to model-ready tensors
Ship models via MLOps best practices (containerization, CI/CD, experiment tracking, monitoring, model cards)
Work closely with technology development, software, product, medical, and regulatory teams to turn models into patient-impacting products
Author clear technical docs and present results to scientific and executive audiences
Qualification
Required
PhD (CS/EE/Bioinformatics/Statistics/Applied Math or related) or MS with equivalent experience
Strong ML/AI depth with hands-on work experience with deep learning (PyTorch)
Proficiency in Python and scientific stack (sklearn); solid software engineering skills (tests, code review, version control)
Experience with large-scale data, distributed compute, containerization (Docker) and cloud (AWS/GCP/Azure)
Domain expertise in analysis of genomic data: cfDNA (SNVs/indels/CNAs), methylation/epigenomics, fragmentomics, RNA-seq
Track record of publications, patents and conference presentations
Company
Guardant Health
Guardant Health is a precision oncology company that uses blood tests, data sets, and analytics to provide treatment to cancer patients.
Founded in 2012
1001-5000 employees
H1B Sponsorship
Guardant Health has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (38)
2024 (50)
2023 (40)
2022 (72)
2021 (57)
2020 (29)
Funding
Current Stage
Public CompanyTotal Funding
$2.53BKey Investors
Baillie GiffordSoftBank Vision FundOrbiMed
2025-11-05Post Ipo Equity· $284.4M
2025-11-05Post Ipo Debt· $350M
2023-12-21Post Ipo Equity· $90.7M
Leadership Team
AmirAli Talasaz
Co-founder and Co-Chief Executive Officer
Helmy Eltoukhy
Chairman and Co-Chief Executive Officer
Recent News
2026-01-12
Company data provided by crunchbase