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Calico Life Sciences · 3 hours ago

Intern, Protein Biochemistry - Structural Biology (BS)

South San Francisco, CA

Internship

Onsite

Intern

$45/hr - $70/hr

Start in 2026 Summer

Calico Life Sciences is an Alphabet-founded research and development company focused on understanding human aging. They are seeking an intern to join the Protein Science group, where the intern will work on the structural and functional characterization of proteins and collaborate with other teams to provide mechanistic insights.

Responsibilities

Express and purify recombinant proteins

Play an active role in structural determination and assessment of protein-protein and protein-ligand interactions

Perform and optimize protein activity and/or binding assays

Communicate scientific results in a group setting

Qualification

Recombinant protein expressionProtein purificationMolecular biology principlesProtein biochemistry knowledgeFlexibleTeamwork skillsCommunication skillsDetail-orientedSelf-motivated

Required

Currently pursuing a BS degree in biology, biochemistry, biological sciences or related field

Experience working with recombinant proteins (expression in E. coli and mammalian systems, multi-step-purification, analysis, and structural determination)

Knowledge of general principles of molecular biology and protein biochemistry

A strong interest in protein biochemistry

Detail-oriented and organized

Strong teamwork and communication skills

Self-motivated with a 'can-do' attitude

Flexible, able to respond quickly to shifting priorities and able to multitask

Able to work in-person at our offices in South San Francisco

Free for a consecutive period of 11-12 weeks in June, July, and August

Not graduating before December 2026

Must be enrolled in a US university

Must apply by application deadline: February 1, 2026

Preferred

Familiarity with experimental structural biology techniques

Prior experience with protein binding or functional assays would be helpful as would experience using an electronic notebook (such as Benchling), online registries (UniProt, NCBI, Protein Data Bank), and using software to design DNA plasmids (SnapGene) and to analyze protein structures (PyMol or ChimeraX)

Benefits

Monthly living expenses stipend

Company

Calico Life Sciences

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Calico is an Alphabet-founded research and development company whose mission is to harness advanced technologies.

Founded in 2013

South San Francisco, California, USA

201-500 employees

http://www.calicolabs.com/

H1B Sponsorship

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