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Calico Life Sciences · 1 month ago

Intern, Biophysical Characterization of 𝝰-synuclein in Living Cells (PhD Only)

South San Francisco, CA

Internship

Onsite

Intern

$45/hr - $70/hr

Start in 2026 Summer

Calico is seeking an intern to join the Parkinson’s Disease Initiative, focusing on the biophysical characterization of 𝝰-synuclein in living cells. The intern will develop a novel imaging-based experimental system and work closely with the imaging team to explore synuclein dynamics and its regulation by disease-relevant perturbations.

Responsibilities

Optimize a genetic code expansion approach to site-specifically label alpha synuclein with fluorophores

Proof-of-concept implementation of the labeling system in cell culture

Perform biophysical characterization of labeled synuclein using rotational diffusion methods fluorescence polarization and tumbling methods in vitro and in living cells

Explore experimental perturbations to induce changes in synuclein trafficking, oligomerization, aggregation and clearance

Qualification

Fluorescence microscopyFlow cytometryQuantitative imaging analysisMolecular biology methodsFlexibleTeamwork skillsCommunication skillsDetail-orientedSelf-motivated

Required

Currently pursuing a PhD degree, in biophysics, cell biology, neuroscience or a related field

Experience working with fluorescence microscopy, flow cytometry

Knowledge of physical modeling of biological processes, quantitative imaging analysis

Familiarity with standard molecular biology and tissue culture methods

Detail-oriented and organized

Strong teamwork and communication skills

Self-motivated with a 'can-do' attitude

Flexible, able to respond quickly to shifting priorities and able to multitask

Preferred

Experience in genetic screening, codon expansion system, Parkinson's disease

Benefits

Competitive compensation ($45 - $70/hour)

Monthly living expenses stipend

Company

Calico Life Sciences

Glassdoor4.1

Calico is an Alphabet-founded research and development company whose mission is to harness advanced technologies.

Founded in 2013

South San Francisco, California, USA

201-500 employees

http://www.calicolabs.com/

Funding

Current Stage

Growth Stage

Leadership Team

Ashley Archuleta

Sr. Administrative Assistant to the Chief Business Officer

Jonathan Lewis

Chief Business Officer

Recent News

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