Alnylam Pharmaceuticals · 1 month ago
Senior Director, Lab-to-Product Platform and Operations Technology
Cambridge, MA
Full-time
Hybrid
Director/Executive
$227K/yr - $307K/yr
15+ years expAlnylam Pharmaceuticals is seeking a strategic and pragmatic technology leader for the role of Senior Director, Lab-to-Product Platform & Operations Technology. This role is responsible for owning and operating core digital platforms and operational technologies that support laboratory operations and external execution partners, ensuring seamless interoperability and operational efficiency.
BiotechnologyHealth CareMedicalPharmaceuticalTherapeutics
Responsibilities
Own and operate core lab, plant, and external partner operational platforms
Lead the digital capabilities that support lab operations across Research, CMC, and QC, including LIMS, ELN/LES, sample & inventory management, registration, lab automation enablement, instrument integration, lab computing, lab system validation, and operational data capture
Oversee plant-floor operational technologies (OT) such as equipment/instrument connectivity, environmental and facility monitoring interfaces, materials tracking, barcode/RFID data capture, and automated data collection (excluding MES and supply chain systems)
Enable operational technology connectivity, workflow interoperability, and validated data exchange with CROs, external research labs, development partners, contract testing labs, and external manufacturers
Support validated data handoffs, sample/material traceability, workflow tracking, and operational interfaces across hybrid (internal + external) execution models
Ensure reliability, compliance, validated state, lifecycle management, and service continuity across internal systems and partner-connected operational interfaces
Oversee lab/operational system validation activities in partnership with Quality to maintain GxP compliance and data integrity across all execution environments
Build the Lab-to-Product Platform (Internal + External Execution Model)
Architect and deliver the operational platform that connects experiment execution → sample workflows → QC testing → plant operational activities → external execution and release workflows
Provide reusable platform components including metadata standards, workflow modules, instrument connectors, validated integration frameworks, and operational data pipelines that external partners can adopt or interface with
Ensure seamless interoperability with: + Scientific platforms owned by ReDev Technology + Manufacturing/enterprise systems owned by Manufacturing/CMC/Supply Chain Technology + External research, development, QC, and manufacturing partner systems
Establish secure, scalable, validated patterns for partner connectivity (e.g., APIs, secure file exchange, partner portals, event/data streams)
Lead a high-performing operations-focused technology team
Build and develop talent and capabilities across product management, engineering/architecture, lab computing support, instrument connectivity, and operational platform engineering
Define support, governance, onboarding, and escalation models for external partners, including SLAs and service continuity plans in collaboration with ReDev and TOQ
Drive a culture centered on operational excellence, validation rigor, compliance, accountability, and pragmatic problem-solving
Establish standards, governance, and best practices for lab/plant operational technology, including lab system validation frameworks
Deliver robust operational data integration
Work closely with the Data & AI organization to ensure operational data – including external partner-generated data - is structured, contextualized, and AI-ready
Implement consistent metadata, data capture, and validated interface practices across internal and external operations
Enable cross-system visibility into workflows, materials, samples, and processes across internal labs, plants, and external partner networks
Partner deeply across the enterprise and external ecosystem
Collaborate with ReDev Technology, Manufacturing/CMC/Supply Chain Technology, Quality, Tech Operations, Data/AI, Infrastructure, and Security to ensure cohesive integration and operational excellence
Partner with ReDev and TOQ to define and support the digital operating model for CROs, external labs, contract testing labs, and external manufacturers
Maintain clear ownership boundaries while ensuring the operational platform enables distributed execution
Serve as a trusted partner to scientific, operational, and quality stakeholders – internally and externally
Qualification
Required
Bachelor's degree in Computer Science, Engineering, Life Sciences, or related field (or equivalent experience)
15+ years of progressive leadership experience in laboratory informatics, scientific operations, OT/plant-floor (shop floor) automation enablement, or manufacturing operational technology in biotech/pharma
Deep expertise with lab operations systems (e.g., LIMS, ELN/LES, sample/inventory management, workflow orchestration), lab computing environments, instrument integration, and validated interfaces
Experience supporting operational workflows across internal and external networks, including CROs, external research labs, contract testing labs, and/or external manufacturers
Strong understanding of GxP, Computer System Validation (CSV), data integrity, interoperability, and operational data management
Experience leading product management and engineering/architecture teams in regulated and non-regulated environments
Proven track record delivering enterprise-scale operational platforms with measurable impact
Exceptional communication, influence, and stakeholder-management skills
Ability to balance long-term strategy with pragmatic execution
Preferred
Advanced degree in Computer Science, Engineering, or Life Sciences
Experience supporting RNAi, oligonucleotide, or other advanced modality development or manufacturing
Familiarity with modern integration architectures (APIs, event-driven patterns), lab automation frameworks, OT/plant-floor technologies, and emerging AI-driven automation
Experience in environments where R&D, CMC, QC, Manufacturing, and external partners depend on shared operational platforms and validated systems
Benefits
Comprehensive benefits including medical, dental, and vision coverage
Life and disability insurance
A lifestyle reimbursement program
Flexible spending and health savings accounts
A 401(k) with a generous company match
Paid time off
Wellness days
Holidays
Two company-wide recharge breaks
Generous family resources and leave
Company
Alnylam Pharmaceuticals
Alnylam Pharmaceuticals is a biopharmaceutical company focused on the discovery, development and commercialization.
1001-5000 employees
H1B Sponsorship
Alnylam Pharmaceuticals has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2022 (18)
2021 (19)
2020 (7)
Funding
Current Stage
Public CompanyTotal Funding
$4.55BKey Investors
Blackstone Life SciencesBlackstone CreditRegeneron
2025-09-09Post Ipo Debt· $661.25M
2022-09-12Post Ipo Debt· $900M
2022-03-04IPO
Leadership Team
Yvonne Greenstreet
Chief Executive Officer
Jeff Poulton
Chief Financial Officer
Recent News
Business Wire
2026-01-12
2025-12-22
Company data provided by crunchbase