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Calico Life Sciences · 12 hours ago

Intern, Biophysical Characterization of 𝝰-synuclein in Living Cells (PhD Student)

South San Francisco, CA

Internship

Onsite

Intern

$45/hr - $70/hr

Start in 2026 Summer

Calico Life Sciences is an Alphabet-founded research and development company focused on understanding human aging. The intern will develop a novel imaging-based experimental system to study 𝝰-synuclein dynamics in vitro and in living cells, working closely with the Parkinson’s Disease Initiative team.

Responsibilities

Optimize a genetic code expansion approach to site-specifically label alpha synuclein with fluorophores

Proof-of-concept implementation of the labeling system in cell culture

Perform biophysical characterization of labeled synuclein using rotational diffusion methods fluorescence polarization and tumbling methods in vitro and in living cells

Explore experimental perturbations to induce changes in synuclein trafficking, oligomerization, aggregation and clearance

Qualification

Fluorescence microscopyFlow cytometryQuantitative imaging analysisGenetic screeningCodon expansion systemMolecular biology methodsFlexibleDetail-orientedTeamworkCommunication skillsSelf-motivated

Required

Currently pursuing a PhD degree, in biophysics, cell biology, neuroscience or a related field

Experience working with fluorescence microscopy, flow cytometry

Knowledge of physical modeling of biological processes, quantitative imaging analysis

Familiarity with standard molecular biology and tissue culture methods

Detail-oriented and organized

Strong teamwork and communication skills

Self-motivated with a 'can-do' attitude

Flexible, able to respond quickly to shifting priorities and able to multitask

Preferred

Experience in genetic screening, codon expansion system, Parkinson's disease

Benefits

Monthly living expenses stipend

Group supplemental activities weekly featuring guest speakers, Senior Leadership spotlights, and discussion groups on aging science, our drug development approach, and more

End-of-summer company-wide project showcase and poster session