Janux Therapeutics · 17 hours ago
Director, Clinical Pharmacology Lead
San Diego County, CA
Full-time
Onsite
Director/Executive
$232K/yr - $254K/yr
6+ years expJanux Therapeutics is seeking a hands-on, execution-driven Clinical Pharmacology Lead to support the design, analysis, and interpretation of clinical pharmacology strategies across their development programs. This role focuses on executional excellence and involves leading clinical pharmacology plans, ensuring data quality, and collaborating with various teams to integrate pharmacological insights into development programs.
BiotechnologyHealth DiagnosticsPharmaceuticalTherapeutics
Responsibilities
Serve as the Clinical Pharmacology Lead across multiple programs, owning the execution of clinical pharmacology plans from IND through early clinical development
Design and oversee PK, PK/PD, and exposure-response analyses to support dose selection, study design, and benefit-risk assessments
Lead the development and execution of clinical pharmacology components of studies, including food effect, drug-drug interaction, organ impairment, and QT assessments
Author and review clinical pharmacology sections of regulatory documents (e.g., INDs, NDAs, briefing books) and support regulatory interactions
Ensure proper bioanalytical sampling strategies, assay validation, and data quality across studies
Collaborate with Translational Medicine and Biomarker teams to integrate mechanistic and biomarker data into PK/PD interpretation
Work closely with Biometrics and external modeling partners to support population PK and exposure-response modeling
Stay current with regulatory guidance and scientific advances in clinical pharmacology, applying best practices to development programs
Contribute to program-level planning and prioritization based on pharmacological insights and development risk
Other activities as required
Qualification
Required
Ph.D., Pharm.D., or equivalent in Clinical Pharmacology, Pharmaceutical Sciences, or a related field
6+ years of experience in clinical pharmacology and/or pharmacometrics in the biotech or pharmaceutical industry
Direct experience designing and executing early-phase clinical studies, including healthy volunteer studies
Strong expertise in PK analysis and exposure-response interpretation; experience in oncology or biologics preferred
Familiarity with T cell engagers (TCE) and managing external Clinical Pharmacology resources
Proven track record of contributing to regulatory submissions and engaging with health authorities
Excellent communication, collaboration, and organizational skills
Ability to work independently and in a fast-paced, matrixed environment
Ability to travel up to 15%
Preferred
Experience in oncology or biologics preferred
Benefits
Annual bonus program
Incentive stock option plan
401k plan with flat non-elective employer contribution
Comprehensive medical insurance with 90-100% employer-paid premiums
Dental and vision insurance
HSA, FSA, and supplemental insurance plans (life, disability, accident, critical illness, hospital indemnity)
Unlimited PTO
Generous holiday schedule; includes summer and winter company shutdown
Relocation assistance
Company
Janux Therapeutics
Janux Therapeutics develops immunotherapies that generates immune responses to prevent tumors and not affecting a patient’s healthy tissue.
51-200 employees
Funding
Current Stage
Public CompanyTotal Funding
$898.94MKey Investors
RA Capital ManagementAvalon Ventures
2024-12-03Post Ipo Equity· $350M
2024-02-29Post Ipo Equity· $296.5M
2023-07-17Post Ipo Equity· $60M
Leadership Team
David Campbell
President, CEO & Director (Founder)
Byron Robinson
Chief Strategy Officer
Recent News
2025-12-24
2025-12-04
2025-12-03
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