Apply on Employer Site

Calico Life Sciences · 1 month ago

Intern, Lung Aging (PhD Student)

South San Francisco, CA

Internship

Onsite

Intern

$45/hr - $70/hr

Start in 2026 Summer

Calico is a research and development company focused on understanding the biology of human aging. The intern will work in the Gillich lab, using CRISPR screening and functional genomics to discover lung aging targets and contribute to understanding mechanisms of aging and disease pathologies in the lung.

Responsibilities

Establish alveolar organoid-fibroblast co-cultures

Transduce alveolar cells with lentiviral library

Establish and employ phenotypic readouts (e.g., immunostaining, reporters)

Analyze and interpret imaging and functional genomics data

Contribute to screening strategy and gRNA library design

Qualification

CRISPR screeningFunctional genomicsGene deliveryOrganoids experienceFluorescence microscopyImmunostainingRNA-seq analysisFlexibleTeamwork skillsCommunication skillsDetail-orientedSelf-motivated

Required

Currently pursuing a PhD degree, in cellular and molecular biology or related fields

Experience working with organoids and/or co-culture systems

Experience with gene delivery (e.g., viral transduction)

Experience with fluorescence microscopy and immunostaining

Experience with the CRISPR/Cas system

Detail-oriented and organized

Strong teamwork and communication skills

Self-motivated with a 'can-do' attitude

Flexible, able to respond quickly to shifting priorities and able to multitask

Preferred

Experience with phenotypic and/or CRISPR screening

Knowledge of NGS library preparation, including 10x Genomics single cell gene expression library preparation

Experience with Python and/or R, including single-cell and bulk RNA-seq data analysis

Benefits

Monthly living expenses stipend

Group supplemental activities weekly featuring guest speakers, Senior Leadership spotlights, and discussion groups on aging science, our drug development approach, and more

End-of-summer company-wide project showcase and poster session