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Partner Therapeutics · 1 day ago

Senior Scientist, Sr. Scientist, Downstream Process Science

Greater Seattle Area

Full-time

Hybrid

Senior Level

$140K/yr - $165K/yr

5+ years exp

Partner Therapeutics is a company focused on drug substance and drug product development. They are seeking a Senior Scientist in Downstream Process Science to lead and execute downstream purification development, manage projects, and provide technical support for cGMP manufacturing operations.

BiotechnologyHealth CareMedicalMedical DeviceTherapeutics

Comp. & Benefits

Hiring Manager

Jennifer Marks, PHR

Responsibilities

Ownership of small-scale downstream purification development, including process optimization, characterization of parameters, and troubleshooting

Designs and performs lab studies using DOE methodology to advance process development knowledge at benchtop scale for characterization, optimization, and/or transfer to manufacturing scale

Project management of downstream purification projects and direct supervision of downstream research associate/s

Hands-on operation and maintenance of semi-preparative chromatography, membrane technology, and low-pressure chromatography (ion exchange, affinity, size exclusion) systems

Provides downstream technical support for cGMP manufacturing operations by contributing insights to solve difficult technical issues and works to build alignment around complex situations

Authors documents to support regulatory filings and commitments

Effectively communicates and collaborates with scientists across the organization

Maintains high-quality and organized records and documentation

Resolves persistent issues by ensuring timely issue escalation to Leadership and cross-functional teams: Applies learning from these events and leads the creation of new/updated systems, processes, programs to prevent similar situations in the future

Through self-education and external networking/participation in industry and professional organizations keeps abreast of current industry trends, compliance requirements, and best-of-class technologies relating to area of responsibility. Actively applies learned best practices, knowledge, and benchmarking to PTx projects and solutions

Pursues participation or leads project teams outside normal course of work (i.e. “collateral duties”) as they become available to support personal growth, connection, and business needs

Adheres to all applicable regulations and requirements including compliance with internal SOPs, GMP, Health and Safety, WISHA/OSHA, regulatory compliance, company policies, and employment-related laws and statutes

Successfully completes all mandatory Quality and Compliance training within required timeframes

Provides leadership and direction to the Downstream Process Development team to ensure KPIs are consistently met while demonstrating and embodying PTx leadership values

Establishes individual goals and objectives in alignment with department goals and priorities. Identifies performance improvement targets and metrics. Ensures capabilities and capacity are in place to effectively deliver on all departmental commitments and performance targets

Recommends and allocates resources - human, technical, etc. - to fulfill near term goals and commitments while building towards sustainable excellence

Builds, develops, inspires, motivates, and leads a diverse, professional team. Sustains high performance that is strongly aligned and coordinated with other functional groups across the organization; ensures Partner engagement by creating a culture of inclusion, execution, and an environment within which they can excel and continuously improve

Works pro-actively and in close collaboration with upline Leadership Team and People & Culture to recruit, hire, grow, and retain a diverse team of talent

Manages and develops the performance of direct reports by setting clear SMART goals, provides and seeks timely performance feedback, recognizes and rewards high achievers, and holds team members accountable for underperformance. Leads by example and promotes PTx’s core Values: Learn, Prepare, Innovate, Collaborate, Lead to continually improve the Quality Culture at PTx

Meets consistently with all Direct Reports in the GOOD 1:1 format and as a team to ensure 2-way updates, conversations, and alignment on goals and priorities are clear and reinforced regularly

Through active leadership and coaching, while embracing PTx’s Values and Behaviors, holds Team accountable for compliance to all safety and quality regulations, ensures all team members directly or indirectly support cGMP activities, and have the necessary education, knowledge, and skills to perform their job in accordance with applicable procedures and regulations

Pro-actively creates opportunities to develop their Team, including ensuring career paths have been developed for Partners (as needed), and enhances the Team through cross-training others, identifying competency gaps, etc

Qualification

Protein PurificationDesign-of-Experiments (DOE)HPLCFDA Regulatory submissionsChromatography SystemsProject ManagementAnalytical SkillsTeam BuildingMS Office ProficiencyLeadership SkillsCommunication SkillsOrganizational SkillsInterpersonal SkillsConflict ResolutionAdaptabilityFeedback Skills

Required

Experience with Protein Purification using Preparative HPLC

Experience with multi-factor Design-of-Experiments (DOE)

Detail-oriented with the ability to independently perform laboratory experiments following a standard operating procedure

Strong critical thinking, analytical, and problem-solving skills with the proven ability to formulate solutions to propel the organization forward

Resourceful with proven ability to lead, manage, and leverage an extensive internal network of stakeholders, team members, and external resources to plan and resolve issues. Strong, collaborative relationship management and interpersonal skills required to quickly gain confidence of stakeholders and team members

Possesses strong organizational and prioritization skills to maintain a high level of productivity and priority-setting in order to complete assignments on-time and on-budget

Excellent soft skills including a bias towards action, the ability and willingness to give and receive constructive feedback, is comfortable working within a diverse team and across multiple functions, exhibits a consistently constructive attitude, and is adaptable and at ease with handling unexpected changes and challenges

Solid English language communication skills, both oral and written, are required for this highly collaborative role. Willingness and ability to clearly express opinions and ask questions. Comfortable actively participating in cross-functional meetings

Proficiency with MS Office products, especially Word and Excel essential; ability and willingness to quickly adopt other job-specific applications will be necessary

Proven ability to lead teams and/or projects effectively while operating in an evolving, complex and dynamic environment

Demonstrated commitment to fostering the professional growth and development of others

Knowledge of standard interviewing protocols; recent experience participating in the hiring process as an interviewer or hiring manager. Formal interview training is a plus

Strong leadership skills including a demonstrated ability to drive accountability and build a departmental culture of trust, compliance, efficiency, and continuous improvement

Proven ability to enhance engagement by creating an environment within which individuals and teams can excel and continuously improve

Skilled at active listening, conflict resolution, and team building

Experience working collaboratively with HR/People & Culture functions to recruit, hire, grow, and retain talent

Formal training in essential people management skills

BS in Engineering or Chemistry with 12+ years of relevant industry experience; MS with 8+ years; or PhD with 5+ years of relevant industry experience

2+ years of direct experience in People Leadership. People Leadership qualification includes experience in recruiting, making hiring decisions, setting SMART Goals, growing high performers, and addressing performance concerns