GSK · 4 months ago
Principal Scientist, Discovery DMPK Bioanalytical
USA - Pennsylvania - Upper Providence
Full-time
Onsite
Senior Level, Lead/Staff
5+ years expGSK is a global biopharma company dedicated to improving health through innovation in specialty medicines and vaccines. The Discovery DMPK bioanalyst will analyze molecules across GSK’s portfolio, utilizing mass spectrometry skills to support discovery programs and drive projects forward in a fast-paced laboratory environment.
BiotechnologyHealth CarePharmaceutical
Responsibilities
Working within the Discovery DMPK group, you will utilize your lab-bench technical knowledge and apply your experience in LC-MS approaches to support GSK’s portfolio deliverables
This role will work across modalities (large/small molecule, oligonucleotides, etc.) but provide key leadership as a subject matter expert in large molecule LC-MS bioanalysis
In this position, you will have the opportunity to plan, develop, and execute on our objective to provide the large molecule LC-MS analyses required by our evolving portfolio
Working across boundaries, you will help define the trajectory of our LC-MS approaches for biologics, collaborating cross-functionally to understand areas of need and delivering to those goals
By establishing best practices for sample preparation, quantitation strategies, and data analysis you will drive projects forward while building organizational expertise in biopharmaceutical bioanalysis
Qualification
Required
Ph.D. in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or a related discipline, with 2+ years of postdoctoral/industry experience; or M.S. with 5+ years; or B.S. with 8+ years
Experience in mass spectrometry -based analysis of biopharmaceutics (e.g., antibodies, antibody-drug conjugates)
Experience in implementing new instrumentation, technology, and workflows to solve challenging analytical problems
Experience with high resolution mass spectrometry instrumentation and data analysis
Laboratory experience analyzing DMPK/related assays (in vitro, in vivo, toxicokinetic) using mass spectrometry
Preferred
Proficient in using and troubleshooting Sciex mass spectrometers, including Time-of-Flight instruments
Experience with the bioanalysis of oligonucleotide therapeutics (siRNA, ASOs, or related modalities)
Prior involvement in matrix leadership, including leading cross-functional initiatives or guiding scientific strategy across multiple teams
Familiarity with regulatory expectations for large molecule bioanalysis
Company
GSK
We are uniting science, technology and talent to get ahead of disease together. Our community guidelines: https://gsk.to/socialmedia
10001+ employees
H1B Sponsorship
GSK has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (45)
2024 (56)
2023 (54)
2022 (53)
2021 (54)
2020 (72)
Funding
Current Stage
Public CompanyTotal Funding
$25.51MKey Investors
CARB-X
2021-03-02Grant· $18M
2020-09-23Grant· $7.51M
1978-01-13IPO
Leadership Team
Julie Brown
CFO
Mike Elmore
SVP & Chief Information Security Officer, GSK
Recent News
South China Morning Post
2026-01-08
2026-01-07
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