GSK · 12 hours ago
Principal Downstream Scientist – mRNA purification
Cambridge, MA
Full-time
Onsite
Senior Level, Lead/Staff
$113K/yr - $188K/yr
3+ years expGSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. As a Principal Downstream Scientist specializing in mRNA purification, you will design and optimize purification processes, collaborate with cross-functional teams, and contribute to the development of scalable solutions for innovative vaccine platforms.
BiotechnologyHealth CarePharmaceutical
Responsibilities
Design, execute, and analyze experiments to develop and optimize mRNA purification processes
Ensure processes are scalable and phase-appropriate for clinical manufacturing
Collaborate with global teams, including analytical R&D, GMP, and process development colleagues
Drive innovative solutions to improve purification techniques and meet project milestones
Stay current with industry trends and emerging technologies in downstream processing
Maintain detailed documentation to ensure data integrity and compliance
Qualification
Required
Master's or PhD. degree in Molecular Biology, Biotechnology, Bioengineering, Chemical Engineering, or a related field
Five years (Master's) or Three years (PhD.) of industry experience in downstream process development for large biomolecules, including mRNA or pDNA
Three or more years of experience with purification techniques such as affinity capture, ion exchange, and hydrophobic interactions
Three or more years of experience supporting CMC activities, including process and analytical development
Preferred
PhD in Molecular Biology, Biotechnology, Bioengineering, Chemical Engineering, or a related field
Experience with Quality by Design principles and DOE studies for process optimization
Knowledge of regulatory guidelines (FDA/ICH/ISPE) for process validation and technology transfer
Familiarity with nucleic acid analytical technologies
Strong problem-solving skills and ability to work collaboratively in a matrixed environment
Benefits
Health care and other insurance benefits (for employee and family)
Retirement benefits
Paid holidays
Vacation
Paid caregiver/parental and medical leave
Company
GSK
We are uniting science, technology and talent to get ahead of disease together. Our community guidelines: https://gsk.to/socialmedia
10001+ employees
H1B Sponsorship
GSK has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (45)
2024 (56)
2023 (54)
2022 (53)
2021 (54)
2020 (72)
Funding
Current Stage
Public CompanyTotal Funding
$25.51MKey Investors
CARB-X
2021-03-02Grant· $18M
2020-09-23Grant· $7.51M
1978-01-13IPO
Leadership Team
Julie Brown
CFO
Mike Elmore
SVP & Chief Information Security Officer, GSK
Recent News
EIN Presswire
2025-11-24
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